BLM
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Official Full Name
Bloom syndrome, RecQ helicase-like -
Overview
The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3-5 helicase activity.The normal protein may act to suppress inappropriate recombination. -
Synonyms
BLM;Bloom syndrome, RecQ helicase-like;Bloom syndrome;Bloom syndrome protein;BS;RECQ2;RECQL3;recQ protein-like 3;DNA helicase, RecQ-like type 2;RECQL2;MGC126616;MGC131618;MGC131620
Recombinant Proteins
- Chicken
- Mouse
- Human
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- His
- GST
- His&Fc&Avi
- His&Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| BLM-1738C | Recombinant Chicken BLM | Mammalian Cell | Chicken | His |
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| BLM-2415M | Recombinant Mouse BLM Protein | Mammalian Cell | Mouse | His |
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| BLM-241H | Recombinant Human BLM Protein, GST-tagged | Wheat Germ | Human | GST |
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| BLM-1040M | Recombinant Mouse BLM Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| BLM-1040M-B | Recombinant Mouse BLM Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| BLM-2206M | Recombinant Mouse BLM Protein (684-859 aa), His-Myc-tagged | E.coli | Mouse | His&Myc | 684-859 aa |
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| BLM-34H | Recombinant Human BLM Protein | E.coli | Human |
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| BLM-675H | Recombinant Human BLM protein, His-tagged | E.coli | Human | His | 877-1024aa |
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Involved Pathway
BLM involved in several pathways and played different roles in them. We selected most pathways BLM participated on our site, such as Homologous recombination,Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BLM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Homologous recombination | BRCA2,POLD4,POLD2,POLD1,RAD51D,RAD51,RAD52,RAD51L1,SSBP1,TOP3B |
| Fanconi Anemia Pathway | FANCG,POLN,BRCA1,RMI1,FANCL,TOP3B,FANCC,POLK,FANCI,FANCF |
Protein Function
BLM has several biochemical functions, for example, ATP binding,ATP-dependent 3-5 DNA helicase activity,ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BLM itself. We selected most functions BLM had, and list some proteins which have the same functions with BLM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| four-way junction helicase activity | WRN |
| p53 binding | TP53RK,CDK5,CHD8,BANP,TRP63,ZNF346,MAPKAPK5,ZNF385A,USP10,EP300 |
| helicase activity | DICER1,DDX11,GTF2F2A,GTF2F2,DHX58,DHX36,CHD7,DDX19,DNA2,HELLS |
| single-stranded DNA binding | XRCC2,FUBP1,SSBP3,TSN,PCBP1,SSBP2,ALYREF,CNBPA,ERCC1,NME2 |
| protein binding | PTK6,SEPT2,UBA52,ZBTB1,NUDT4,RAD23A,ZNF622,KANK2,HIP1,CCR5 |
| DNA binding | RAD51L1,FOXO1A,TFIP11,DRL,ZSCAN4F,KDM2B,ZFP146,AHCTF1,TERT,PROX1 |
| bubble DNA binding | WRN,RECQL4,ERCC5,NEIL3,HMGB1 |
| ATP binding | VWA8,EPHB4,AXL,DDX28,MKNK2A,P2RY1,SPG7,NLRP9B,HSPA14,KIF2A |
| nucleic acid binding | NPM1B,ENPP2,RBM12B2,NELFE,BCL6A,ZFP541,ARIH2,ZKSCAN14,DDX51,MTHFSD |
Interacting Protein
BLM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BLM here. Most of them are supplied by our site. Hope this information will be useful for your research of BLM.
Resources
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References
- Aono, Y; Kishi, M; et al. Role of Platelet-Derived Growth Factor/Platelet-Derived Growth Factor Receptor Axis in the Trafficking of Circulating Fibrocytes in Pulmonary Fibrosis. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 51:793-801(2014).
- Li, J; Wang, G; et al. Transforming growth factor beta regulates beta-catenin expression in lung fibroblast through NF-kappa B dependent pathway. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34:1219-1224(2014).
