BIK
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Official Full Name
BCL2-interacting killer (apoptosis-inducing) -
Overview
Bik/Nbk (Bcl-2-interacting killer/natural born killer) is a potent pro-apoptotic protein belonging to a group of Bcl-2 family members that includes Bad, Bid, Bim, Hrk, and Noxa, containing a BH3 domain but lacking other conserved domains, BH1 or BH2. Func -
Synonyms
BIK;BCL2-interacting killer (apoptosis-inducing);bcl-2-interacting killer;NBK;apoptosis inducer NBK;apoptosis-inducing NBK;BP4;BIP1
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| BIK-219H | Recombinant Human BIK Protein, GST-tagged | Wheat Germ | Human | GST |
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| BIK-220H | Recombinant Human BIK Protein, GST-tagged | Wheat Germ | Human | GST |
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| BIK-2405M | Recombinant Mouse BIK Protein | Mammalian Cell | Mouse | His |
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| BIK-4106Z | Recombinant Zebrafish BIK | Mammalian Cell | Zebrafish | His |
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| BIK-5334C | Recombinant Chicken BIK | Mammalian Cell | Chicken | His |
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| BIK-769H | Recombinant Human BIK Protein, His-tagged | E.coli | Human | His |
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| BIK-65HCL | Recombinant Human BIK lysate | HEK293 | Human | Non |
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| BIK-1033M | Recombinant Mouse BIK Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| BIK-1033M-B | Recombinant Mouse BIK Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| BIK-1626HF | Recombinant Full Length Human BIK Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 160 amino acids |
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| RFL31368HF | Recombinant Full Length Human Bcl-2-Interacting Killer(Bik) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-160) |
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Involved Pathway
BIK involved in several pathways and played different roles in them. We selected most pathways BIK participated on our site, such as Apoptosis Modulation and Signaling,DNA damage response (only ATM dependent), which may be useful for your reference. Also, other proteins which involved in the same pathway with BIK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis Modulation and Signaling | DAXX,CAPNS1,SEPT4,HN1,HRK,CASP2,DFFA,BAG3,PTRH2,BCL2L11 |
| DNA damage response (only ATM dependent) | DVL3,MLKL,DVL2,DVL1 |
Protein Function
BIK has several biochemical functions, for example, BH domain binding,protein binding,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BIK itself. We selected most functions BIK had, and list some proteins which have the same functions with BIK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| BH domain binding | BAK1,BCL2A1A,BOK,BCL2L2,Bcl2a1b |
| protein binding | CNOT6L,ZNF580,HYI,TMEM242,CKM,GAP43,NCLN,POLR3C,KRTAP10-8,GP6 |
| protein heterodimerization activity | PHC2B,TFAP2E,FZD9,SOS1,HIST1H2AA,MID1,TAP1,NPAS4,SMAD1,DRD2 |
Interacting Protein
BIK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIK here. Most of them are supplied by our site. Hope this information will be useful for your research of BIK.
BCL2L2;BCL2;FATE1;BCL2L1;BCL2L1;BCL2A1
Resources
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References
- Albrechtsen, R; Kveiborg, M; et al. ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis and increased tumor growth. JOURNAL OF CELL SCIENCE 126:4707-4720(2013).
- Sung, ES; Park, KJ; et al. The proteasome inhibitor MG132 potentiates TRAIL receptor agonist-induced apoptosis by stabilizing tBid and Bik in human head and neck squamous cell carcinoma cells. EXPERIMENTAL CELL RESEARCH 318:1564-1576(2012).
