BCL9
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Official Full Name
B-cell CLL/lymphoma 9 -
Overview
BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008] -
Synonyms
BCL9;B-cell CLL/lymphoma 9;LGS;B-cell CLL/lymphoma 9 protein;bcl-9;protein legless homolog;B-cell lymphoma 9 protein
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- E. coli
- GST
- His&T7
- His
- His&Fc&Avi
Involved Pathway
BCL9 involved in several pathways and played different roles in them. We selected most pathways BCL9 participated on our site, such as Deactivation of the beta-catenin transactivating complex,Formation of the beta-catenin:TCF transactivating complex,Regulation of Wnt-mediated beta catenin signaling and target gene transcription, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TCF dependent signaling in response to WNT | TNKS2,RSPO3,SOX9A,LGR6,USP34,LGR4,SOX4A,RSPO2,TNKS,SOX9B |
| Formation of the beta-catenin:TCF transactivating complex | BCL9L,TLE3,PYGO2,ASH2L,TLE2,TLE4,RBBP5,TLE3B,H3F3B.1,PYGO1 |
| Deactivation of the beta-catenin transactivating complex | BCL9L,ASH2L,PYGO2,SRY,SOX9A,C,TLE3,TLE4,SOX13,CTBP1 |
| Regulation of Wnt-mediated beta catenin signaling and target gene transcription | CYR61,TNIK,TLE4,MYOG,AES,T,KRT1,CBY1,CDX4,KCNIP4 |
| Signaling by Wnt | WIF1,HECW1B,SOX6,SOX32,CDC73,CCDC88C,SOX4B,KREMEN2,SRY,ROR1 |
| Wnt Signaling Pathway NetPath | TCF4,MARK2,MAP1B,MTAP1B,PAX2,TFAP2A,SALL1,HIPK2,BRD7,ANKRD6 |
| Signal Transduction | METAP2B,GRAP,ARHGAP25,GPR68,MDKA,TAS2R7,ARHGAP9,RYK,RBP3,AES |
Protein Function
BCL9 has several biochemical functions, for example, beta-catenin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL9 itself. We selected most functions BCL9 had, and list some proteins which have the same functions with BCL9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-catenin binding | DACT3,ESR1,NF2,CDH24,CDH2,LZTS2A,BTRC,CHD8,CD2AP,TBL1XR1 |
| protein binding | RFWD3,KISS1R,PAFAH1B3,VAC14,VHL,GIP,RACGAP1,TCEB3,GRB7,RPIA |
Interacting Protein
BCL9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL9 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL9.
PYGO1;PYGO2;CDC73;arm;CTNNB1;h3_peptide_fragment;TCF4;Ctnnb1
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