BCL7A
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Official Full Name
B-cell CLL/lymphoma 7A -
Overview
This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
BCL7A;B-cell CLL/lymphoma 7A;BCL7;B-cell CLL/lymphoma 7 protein family member A;B-cell CLL/lymphoma-7
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- HEK293T
- Yeast
- His
- GST
- Myc&DDK
- His&Myc
- His&Fc&Avi
Involved Pathway
BCL7A involved in several pathways and played different roles in them. We selected most pathways BCL7A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL7A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
BCL7A has several biochemical functions, for example, molecular_function,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL7A itself. We selected most functions BCL7A had, and list some proteins which have the same functions with BCL7A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | SH2D5,LYRM7,TP53AIP1,IMMP1L,HAUS2,LIPN,TIFAB,FHDC1,VMN1R137,Sult2a6 |
| protein binding | C1orf189,SNAPC5,TRPC7,XRCC6,NQO1,GNAQ,TERF2IP,WHSC1,SH3RF2,DRAXIN |
Interacting Protein
BCL7A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL7A here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL7A.
ALAS1;RELB;Bcl7b;Tuba3a;CBX5;MAPK8;Tipin
Resources
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References
- Son, M; Lee, M; et al. Genipin as a novel chemical activator of EBV lytic cycle. JOURNAL OF MICROBIOLOGY 53:155-165(2015).
- Uehara, T; Kage-Nakadai, E; et al. The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway. PLOS GENETICS 11:-(2015).
