BCAR3
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Official Full Name
breast cancer anti-estrogen resistance 3 -
Overview
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. -
Synonyms
BCAR3;breast cancer anti-estrogen resistance 3;breast cancer anti-estrogen resistance protein 3;NSP2;SH2D3B;BCAR 3;Novel SH2 containing protein 2;SH2 domain containing protein 3B;Breast cancer anti estrogen resistance 3;Breast cancer anti estrogen resistance protein 3;Breast cancer antiestrogen resistance 3;dJ1033H22.2;dJ1033H22.2 breast cancer anti estrogen resistance 3;dJ1033H22.2 breast cancer antiestrogen resistance 3;KIAA0554;NSP 2;SH2 containing protein Nsp2;OTTHUMP00000011959;OTTHUMP00000011960;OTTHUMP00000011961;OTTHUMP00000011962;novel SH2-containing protein 2;SH2 domain-containing protein 3B;dJ1033H22.2 (breast cancer anti-estrogen resistance 3)
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- His
- His&GST
- GST
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
BCAR3 involved in several pathways and played different roles in them. We selected most pathways BCAR3 participated on our site, such as Regulation of CDC42 activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCAR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of CDC42 activity | MCF2L,ARHGAP1,RALBP1,DNMBP,ARHGEF25,ARHGAP17,DOCK6,SPATA13,ITSN2,DOCK10 |
Protein Function
BCAR3 has several biochemical functions, for example, guanyl-nucleotide exchange factor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCAR3 itself. We selected most functions BCAR3 had, and list some proteins which have the same functions with BCAR3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| guanyl-nucleotide exchange factor activity | VAV2,RAPGEF4,EIF2B5,VAV3,ARHGEF11,FGD3,GDPGP1,P2RY12,ARFGEF2,PTGIR |
| protein binding | SDC1,FKBP7,EIF2AK2,C1QTNF9,MAP6,FBXO9,FCN1,RP9,RBMS1,MLLT10 |
Interacting Protein
BCAR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCAR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCAR3.
IRS1;NEDD9;ERBB2;MET;KIT;ERBB3;GAB1;4504555;PFAS;RTN3;GOT2;TPM3
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