B3GAT3
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Official Full Name
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) -
Overview
The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product catalyzes the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of proteoglycans. -
Synonyms
B3GAT3;beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I);galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3;GlcAT I;Beta 1,3 glucuronyltransferase 3;EC 2.4.1.135;Galactosylgalactosylxylosylprotein 3 beta glucuronosyltransferase 3;GLCATI;GlcUATI;Glucuronosyltransferase I;Sqv 8 like protein;UDP GlcUA:Gal beta 1,3 GalR glucuronyltransferase;glcUAT-I;OTTHUMP00000236456;OTTHUMP00000236457;OTTHUMP00000236459;Sqv-8-like protein;UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Mus musculus
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Flag
- DDK
- Myc
- Avi
- Fc
Involved Pathway
B3GAT3 involved in several pathways and played different roles in them. We selected most pathways B3GAT3 participated on our site, such as Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate,Glycosaminoglycan biosynthesis - heparan sulfate / heparin,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with B3GAT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | CHST3A,XYLT1,CHST7,CHST15,CHST12,CHSY1,CSGALNACT2,B3GALT6,XYLT2,CHPF2 |
| Glycosaminoglycan biosynthesis - heparan sulfate / heparin | NDST2,XYLT2,EXT2,NDST3,EXT1A,B4GALT7,GLCEA,NDST4,HS3ST5,EXT1B |
| Metabolic pathways | PCCB,CTH,GBA,DGAT1A,ALDOAA,GSS,ALLC,CYP4A12A,QDPRB2,ALG9 |
Protein Function
B3GAT3 has several biochemical functions, for example, galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity,glucuronosyltransferase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by B3GAT3 itself. We selected most functions B3GAT3 had, and list some proteins which have the same functions with B3GAT3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity | B3GAT1A,B3GAT2,B3GAT1 |
| metal ion binding | KDM5BB,MOXD2,PRKAA1,ZBTB8B,CCC2,HMGCLL1,PPAT,HDAC7,DNTT,ZFAND5B |
| protein phosphatase activator activity | CALM,CALM2,CALM1,CALM3 |
| protein binding | SLC11A2,CETN1,RYR1B,TDG,PAPOLA,SPRR2A,AMOTL2A,NR2F2,TSC2,TBX6 |
| glucuronosyltransferase activity | UGT2A5,UGT1A6A,UGT2B3,UGT8A,UGT1A6B,UGT5A3,UGT5A4,UGT5B4,UGT2A1,UGT5D1 |
Interacting Protein
B3GAT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with B3GAT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of B3GAT3.
SEC22B;1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate
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References
- Gogate, SS; Nasser, R; et al. Hypoxic Regulation of beta-1,3-Glucuronyltransferase 1 Expression in Nucleus Pulposus Cells of the Rat Intervertebral Disc Role of Hypoxia-Inducible Factor Proteins. ARTHRITIS AND RHEUMATISM 63:1950-1960(2011).
- Negishi, M; Dong, J; et al. Glucosaminylglycan biosynthesis: what we can learn from the X-ray crystal structures of glycosyltransferases GlcAT1 and EXTL2. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 303:393-398(2003).
