ATP2A3
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Official Full Name
ATPase, Ca++ transporting, ubiquitous -
Overview
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
ATP2A3;ATPase, Ca++ transporting, ubiquitous;sarcoplasmic/endoplasmic reticulum calcium ATPase 3;SERCA3;calcium pump 3;SR Ca(2+)-ATPase 3;adenosine triphosphatase, calcium;calcium-translocating P-type ATPase;ATPase, Ca(2+)-transporting, ubiquitous
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- Sus scrofa (Pig)
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293T
- Mammalian cells
- HEK293
- E.coli expression system
- GST
- Non
- His
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
ATP2A3 involved in several pathways and played different roles in them. We selected most pathways ATP2A3 participated on our site, such as Calcium signaling pathway,cGMP-PKG signaling pathway,Pancreatic secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP2A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alzheimers disease | NDUFA8,NDUFS4,GRIN2A,MAPK1,Atp5g2,CALM1,GRIN2B,CALML3,NDUFS1,NDUFA6 |
| Pancreatic secretion | AMY2A4,RAC1,CLCA3,PLA2G10,Car2,PLA2G12A,PLCB4,CPB2,LOC780933,RAB11A |
| Calcium signaling pathway | CACNA1G,CALM2,PHKA2,CAMK2D2,CHRM2,PLCD1,CALM3A,GRIN2C,SLC8A1A,MYLK2 |
| cGMP-PKG signaling pathway | PIK3CA,ATP1B4,ATP2B4,NFATC1,ITPR1,CREB3L2,PRKCE,SLC25A5,MYLK3,PLCB3 |
Protein Function
ATP2A3 has several biochemical functions, for example, ATP binding,calcium-transporting ATPase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP2A3 itself. We selected most functions ATP2A3 had, and list some proteins which have the same functions with ATP2A3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ABCB9,MAGI1,AK7,ACTG2,RHOBTB3,NAT1,PRKACAA,AKT2,ACTC1,RPS6KA3A |
| calcium-transporting ATPase activity | ATP2C2,ATP2B1,ATP2B4,ATP2C1,ATP2B1B,ATP2B1A,ATP2B2,ATP2B3B,ATP2B3A,ATP2A2B |
| metal ion binding | FOXP1B,ZBTB7C,TRMT13,FEZF2,JAZF1B,HPDB,GTF2H3,SUZ12,ADCY9,NT5M |
Interacting Protein
ATP2A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP2A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP2A3.
NCK1;HLA-A;BRF2;WRAP73;15-deoxy-delta(12,14;env;ERBB2;CFTR;ATF2;HDAC11
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