ATP1B4
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Official Full Name
ATPase, Na+/K+ transporting, beta 4 polypeptide -
Overview
This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ATP1B4;ATPase, Na+/K+ transporting, beta 4 polypeptide;ATPase, (Na+)/K+ transporting, beta 4 polypeptide;protein ATP1B4;X,K-ATPase beta-m subunit;x/potassium-transporting ATPase subunit beta-m
Recombinant Proteins
- Mouse
- Chicken
- Rat
- Human
- Sus scrofa (Pig)
- Mus musculus
- Bovine
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli
- HEK293T
- E.coli expression system
- His
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ATP1B4-2119M | Recombinant Mouse ATP1B4 Protein | Mammalian Cell | Mouse | His |
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| ATP1B4-3443C | Recombinant Chicken ATP1B4 | Mammalian Cell | Chicken | His |
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| ATP1B4-858R | Recombinant Rat ATP1B4 Protein | Mammalian Cell | Rat | His |
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| ATP1B4-968H | Recombinant Human ATP1B4 protein | Wheat Germ | Human | Non |
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| ATP1B4-48HCL | Recombinant Human ATP1B4 lysate | HEK293 | Human | Non |
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| ATP1B4-1150HF | Recombinant Full Length Human ATP1B4 Protein | In Vitro Cell Free System | Human | Full L. 357 amino acids |
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| ATP1B4-1263H | Recombinant Human ATP1B4 protein, His-tagged | E.coli | Human | His | Tyr132-Thr357 |
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| ATP1B4-1535R | Recombinant Rat ATP1B4 protein, His & T7-tagged | E.coli | Rat | His&T7 | Met132~Thr356 |
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| Atp1b4-1765M | Recombinant Mouse Atp1b4 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| ATP1B4-2941H | Recombinant Human ATP1B4 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| ATP1B4-3984H | Recombinant Human ATP1B4 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| ATP1B4-514R | Recombinant Rat ATP1B4 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| ATP1B4-514R-B | Recombinant Rat ATP1B4 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| ATP1B4-853M | Recombinant Mouse ATP1B4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ATP1B4-853M-B | Recombinant Mouse ATP1B4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| RFL25540SF | Recombinant Full Length Pig Protein Atp1B4(Atp1B4) Protein, His-Tagged | E.coli expression system | Sus scrofa (Pig) | His | Full L. Full Length (1-355) |
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| RFL31599RF | Recombinant Full Length Rat Protein Atp1B4(Atp1B4) Protein, His-Tagged | E.coli expression system | Rat | His | Full L. Full Length (1-356) |
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| RFL32807MF | Recombinant Full Length Mouse Protein Atp1B4(Atp1B4) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-356) |
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| RFL3932HF | Recombinant Full Length Human Protein Atp1B4(Atp1B4) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-357) |
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| RFL-8137BF | Recombinant Full Length Bovine Protein Atp1B4(Atp1B4) Protein, His-Tagged | E.coli expression system | Bovine | His | Full L. Full Length (1-355) |
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Involved Pathway
ATP1B4 involved in several pathways and played different roles in them. We selected most pathways ATP1B4 participated on our site, such as cGMP-PKG signaling pathway,cAMP signaling pathway,Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1B4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Carbohydrate digestion and absorption | FXYD2,G6PC2,AMY1A,PIK3CG,HK1,PIK3CB,AMY2A,SLC5A1,PIK3R1,PIK3CA |
| Thyroid hormone signaling pathway | PLCB4,ATP1B1,RCAN2,MAPK1,PIK3CG,PRKACA,ATP2A2,ATP1A1,RCAN1,AKT2 |
| Thyroid hormone synthesis | ATP1A3,GNAS,CANX,PAX8,CREB3L1,ATP1A2,ATP1B1,HSPA5,GPX6,ITPR3 |
| Insulin secretion | KCNN4,CREB3L3,GLP1R,INS1,FXYD2,RYR2,KCNN2,PRKACG,KCNMB2,KCNMB1 |
| Cardiac muscle contraction | CACNA1D,ATP1B3B,SLC9A1,UQCRQ,ATP1B3,COX6A1,SLC8A1,CACNG1,UQCRH,UQCRC2A |
| Pancreatic secretion | RAC1,LOC780933,SLC26A3,ATP2B1,CPA3,ATP1A3,CTRB1,ATP1A2,PRKCB,RAB8A |
| Endocrine and other factor-regulated calcium reabsorption | KLK1B8,PRKACB,KLK1B3,DNM3,BDKRB2,PRKCA,KLK1B26,ATP1B1,CALB1,ATP1B3 |
| Adrenergic signaling in cardiomyocytes | Adcy4,GNAI2B,TNNC1B,MAPK13,ADRB1,CALM,PRKACB,ATP1B2A,MAPK12B,ATP1A3A |
| Proximal tubule bicarbonate reclamation | ATP1A1,ATP1A3,PCK2,AQP1,MDH1,ATP1B1,GLS,SLC9A3,GLS2,Car4 |
Protein Function
ATP1B4 has several biochemical functions, for example, monovalent inorganic cation transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1B4 itself. We selected most functions ATP1B4 had, and list some proteins which have the same functions with ATP1B4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
ATP1B4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1B4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1B4.
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References
- Gao, K; Song, Z; et al. Genetic analysis of the ATP1B4 gene in Chinese Han patients with Parkinson's disease. MOLECULAR BIOLOGY REPORTS 41:2307-2311(2014).
- Sarkozy, M; Zvara, A; et al. Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats. CARDIOVASCULAR DIABETOLOGY 12:-(2013).
