ATIC
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Official Full Name
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase -
Overview
ATIC (AICAR transformylase/IMP cyclohydrolase) belongs to the purH family, expressed in the cytoplasm, predicted molecular weight approximately 65 kD. ATIC catalyzes the penultimate and final steps in the de novo purine nucleotide biosynthesis pathway. AT -
Synonyms
ATIC;5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase;bifunctional purine biosynthesis protein PURH;AICARFT;IMPCHASE;phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase;PURH;AICARFT/IMPCHAS
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Chicken
- Rat
- Mammalian Cell
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Mammalian cells
- HEK293T
- His
- Non
- GST
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ATIC involved in several pathways and played different roles in them. We selected most pathways ATIC participated on our site, such as Purine metabolism,One carbon pool by folate,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATIC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | PDE6B,POLD2,AK8,ADSSL1,NUDT9,PRPS1L1,PDE5A,POLR3A,NT5C1A,ENTPD4 |
| Metabolic pathways | MGAT4C,FUT9,PTS,ALDH6A1,PANK1,PCYT2,PLCB4,GUK1,PLCH2,B3GALT6 |
| One carbon pool by folate | MTHFD1B,MTFMT,SHMT1,MTHFD1,MTR,ALDH1L2,AMT,MTHFD2L,GART,DHFRL1 |
Protein Function
ATIC has several biochemical functions, for example, IMP cyclohydrolase activity,phosphoribosylaminoimidazolecarboxamide formyltransferase activity,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATIC itself. We selected most functions ATIC had, and list some proteins which have the same functions with ATIC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | GIMAP7,USH1G,MCL1A,MITD1,CD200,PLEKHB1,Il6ra,ACTN1,LRRC41,WHRN |
Interacting Protein
ATIC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATIC here. Most of them are supplied by our site. Hope this information will be useful for your research of ATIC.
HNRNPDL;PSTPIP1;SNRPA;NME2;ME2;CDK2;STOM;VHL;ELF3;IKBKE;CMBL;RADIL;NDUFAF1;TRAF6;EGFR;rbsC;q7cgs8_yerpe;q81sa6_bacan;ere_dna
Resources
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References
- Lima, A; Monteiro, J; et al. Prediction of Methotrexate Clinical Response in Portuguese Rheumatoid Arthritis Patients: Implication of MTHFR rs1801133 and ATIC rs4673993 Polymorphisms. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Li, XQ; Hisaoka, M; et al. Expression of anaplastic lymphoma kinase in soft tissue tumors: An immunohistochemical and molecular study of 249 cases. HUMAN PATHOLOGY 35:711-721(2004).
