Atg12
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Official Full Name
ATG12 autophagy related 12 homolog -
Overview
Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 (PubMed 9852036)). -
Synonyms
ATG12;ATG12 autophagy related 12 homolog (S. cerevisiae);Apg12 (autophagy 12, S. cerevisiae) like , APG12 autophagy 12 like (S. cerevisiae) , APG12L;ubiquitin-like protein ATG12;APG12;APG12 autophagy 12 like;autophagy-related protein 12;Apg12 (aut
Recombinant Proteins
- Mouse
- Zebrafish
- Rat
- Human
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Atg12-1523M | Recombinant Mouse Autophagy-Related 12 (Yeast), His-tagged | E.coli | Mouse | His | 1-141 a.a. |
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| ATG12-2074M | Recombinant Mouse ATG12 Protein | Mammalian Cell | Mouse | His |
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| ATG12-8093Z | Recombinant Zebrafish ATG12 | Mammalian Cell | Zebrafish | His |
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| ATG12-842R | Recombinant Rat ATG12 Protein | Mammalian Cell | Rat | His |
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| ATG12-943H | Recombinant Human ATG12 protein, GST-tagged | Wheat Germ | Human | GST |
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| ATG12-8626HCL | Recombinant Human ATG12 293 Cell Lysate | HEK293 | Human | Non |
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| ATG12-1093HF | Recombinant Full Length Human ATG12 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 74 amino acids |
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| ATG12-498R | Recombinant Rat ATG12 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| ATG12-498R-B | Recombinant Rat ATG12 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| ATG12-820M | Recombinant Mouse ATG12 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ATG12-820M-B | Recombinant Mouse ATG12 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
Atg12 involved in several pathways and played different roles in them. We selected most pathways Atg12 participated on our site, such as FoxO signaling pathway,Regulation of autophagy,RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Atg12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RIG-I-like receptor signaling pathway | CASP8,IFNB1,IFNA13,OTUD5,IL8L1,IKBKE,IFNA7,IFNA2,IL12BA,RELA |
| FoxO signaling pathway | SLC2A4,CCNB3,RAF1A,STK11,G6PCA.1,GABARAP,IGF1RB,AKT2L,FOXG1A,IRS4 |
| Regulation of autophagy | INSB,IFNG,IFNA2,IFNA13,ATG4A,ULK2,ATG10,IFNA7,ATG14,ULK3 |
Protein Function
Atg12 has several biochemical functions, for example, Atg8 ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Atg12 itself. We selected most functions Atg12 had, and list some proteins which have the same functions with Atg12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TBC1D24,MGST3,RBM8A,TRAF7,PPP1R9B,FGFR1OP,RFWD3,KLK4,RHO,CNTNAP1 |
| Atg8 ligase activity | ATG3 |
Interacting Protein
Atg12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Atg12 here. Most of them are supplied by our site. Hope this information will be useful for your research of Atg12.
ATG5;ATG16L1;ATG3;CRX;21362046;SF3B1;POP7;GABARAP
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References
- Li, B; Yue, Y; et al. Blockade of macrophage autophagy ameliorates activated lymphocytes-derived DNA induced murine lupus possibly via inhibition of proinflammatory cytokine production. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 32:705-714(2014).
- Otabe, H; Nibuya, M; et al. Electroconvulsive seizures enhance autophagy signaling in rat hippocampus. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 50:37-43(2014).
