ASPN
-
Official Full Name
asporin -
Overview
This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010] -
Synonyms
ASPN;asporin;OS3;PLAP1;PLAP-1;SLRR1C;asporin proteoglycan;asporin (LRR class 1);small leucine-rich protein 1C;periodontal ligament associated protein 1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Wheat Germ
- Mammalian Cell
- In Vitro Cell Free System
- E.coli
- GST
- His
- Non
- His&SUMO
- N-His&C-Myc
- His&GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ASPN-919H | Recombinant Human ASPN protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| ASPN-9234Z | Recombinant Zebrafish ASPN | Mammalian Cell | Zebrafish | His |
|
|
| ASPN-138HCL | Recombinant Human ASPN cell lysate | Human | Non |
|
||
| ASPN-1211HF | Recombinant Full Length Human ASPN Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 384 amino acids |
|
| ASPN-2003H | Recombinant Human ASPN Protein (33-380 aa), His-SUMO-tagged | E.coli | Human | His&SUMO | 33-380 aa |
|
| Aspn-255M | Recombinant Mouse Aspn Protein, His-tagged | E.coli | Mouse | His | Lys16-Lys373 |
|
| ASPN-256H | Recombinant Human ASPN Protein, His-tagged | E.coli | Human | His | Phe57-Met371 |
|
| Aspn-5151M | Recombinant Mouse Aspn protein, His&Myc-tagged | E.coli | Mouse | N-His&C-Myc | 33-373aa |
|
| Aspn-551M | Recombinant Mouse Aspn Protein, His/GST-tagged | E.coli | Mouse | His&GST | Lys16~Lys373 |
|
Involved Pathway
ASPN involved in several pathways and played different roles in them. We selected most pathways ASPN participated on our site, such as ECM proteoglycans,Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASPN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ECM proteoglycans | SPARC,COL9A1,ACAN,FMOD,MATN3,HAPLN1,PTPRS,COMP,MATN1,VCANB |
| Extracellular matrix organization | MATN1,LTBP2,COL28A1A,COL4A6,VCANB,ADAM9,ADAM8,CAPNS1,PCOLCEB,LOXL3 |
Protein Function
ASPN has several biochemical functions, for example, calcium ion binding,collagen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASPN itself. We selected most functions ASPN had, and list some proteins which have the same functions with ASPN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | STIM2,PLCB1,NECAB2,EFHD2,PLA2G2F,FBLN1,PLA2G5,BGLAP,COL4A3BPA,KCNIP3 |
| collagen binding | HSD17B12,ITGA10,GP6,PODN,CTSK,SERPINH1B,PDGFA,CCBE1,PDGFB,MRC2 |
Interacting Protein
ASPN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASPN here. Most of them are supplied by our site. Hope this information will be useful for your research of ASPN.
Resources
Related Services
Related Products
References
- Heo, S; Yang, JW; et al. Mass spectrometric characterization of recombinant rat 5-hydroxytryptamine receptor 1A (5-HT1AR) expressed in tsA201 human embryonic kidney cells. PROTEOMICS 12:3338-3342(2012).
- Dechavanne, C; Guillonneau, F; et al. Mass Spectrometry Detection of G3m and IGHG3 Alleles and Follow-Up of Differential Mother and Neonate IgG3. PLOS ONE 7:-(2012).
