ASH1L
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Official Full Name
ash1 (absent, small, or homeotic)-like -
Overview
This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. -
Synonyms
ASH1L;ash1 (absent, small, or homeotic)-like (Drosophila);histone-lysine N-methyltransferase ASH1L;ASH1;ASH1L1;huASH1;KMT2H;ASH1-like protein;lysine N-methyltransferase 2H;absent small and homeotic disks protein 1 homolog;probable histone-lysine
Recombinant Proteins
- Human
- Mouse
- E. coli
- Mammalian Cell
- E.coli
- Wheat Germ
- HEK293
- N-His&C-FLAG
- His
- His&Flag
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ASH1L-3938H |
Recombinant Human ASH1L protein, His&FLAG-tagged
|
E. coli | Human | N-His&C-FLAG | 2407-2579 aa |
|
| ASH1L-2031M | Recombinant Mouse ASH1L Protein | Mammalian Cell | Mouse | His |
|
|
| ASH1L-30H | Recombinant Human ATAD2, His&FLAG-tagged | E.coli | Human | His&Flag | 2407-2579 a.a. |
|
| ASH1L-47H | Recombinant Human ASH1L protein, GST-tagged | E.coli | Human | GST | 2022-2302 |
|
| ASH1L-48H | Recombinant Human ASH1L protein, His-tagged | E.coli | Human | His | 2046-2330 a.a. |
|
| ASH1L-49H | Recombinant Human ASH1L protein, GST-tagged | E.coli | Human | GST | 2428-2559 |
|
| ASH1L-50H | Recombinant Human ASH1L protein, His-tagged | E.coli | Human | His | 2428-2559 |
|
| ASH1L-905H | Recombinant Human ASH1L protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| ASH1L-790M | Recombinant Mouse ASH1L Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| ASH1L-790M-B | Recombinant Mouse ASH1L Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
ASH1L involved in several pathways and played different roles in them. We selected most pathways ASH1L participated on our site, such as Lysine degradation,Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASH1L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tight junction | PRKCI,ACTB1,AKT1,MYH4,PTEN,CLDN5A,CLDN4,MRAS,PPP2R1A,TJP2A |
| Lysine degradation | PLOD1A,ACAT2,SETD8B,GLT25D1,COLGALT2,WHSC1L1,PIPOX,SUV39H1,HYKK.2,SETDB2 |
Protein Function
ASH1L has several biochemical functions, for example, DNA binding,chromatin binding,histone methyltransferase activity (H3-K36 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by ASH1L itself. We selected most functions ASH1L had, and list some proteins which have the same functions with ASH1L. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histone methyltransferase activity (H3-K4 specific) | SMYD1B,SETD3,KMT2A,MLL5,SETMAR,WDR82,KMT2E,MLL1,WHSC1L1,WBP7 |
| DNA binding | ZNF157,HSF5,HNF1B,TRIM28,HIST1H4A,SET,ZFP143,NKX2-5,NR1D4A,SP4 |
| zinc ion binding | RERE,ZZEF1,SHPRH,PDZRN3,TP53I3,ZDHHC20,TRIM72,TIMM13,TLL1,DNPEP |
| chromatin binding | KDM8,TRP53,ESR1,TMPOA,RDBP,PPARG,BEND6,RFX4,KDM5A,PRDM13 |
| histone methyltransferase activity (H3-K36 specific) | NSD1,SETMAR,SETD2,SMYD2,SMYD2B,SETD3,SMYD2A |
Interacting Protein
ASH1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASH1L here. Most of them are supplied by our site. Hope this information will be useful for your research of ASH1L.
SMAD7;mtlA
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