ARX

  • Official Full Name

    aristaless related homeobox

  • Overview

    This gene is a homeobox-containing gene expressed during development. The expressed protein contains two conserved domains, a C-peptide (or aristaless domain) and the prd-like class homeobox domain. It is a member of the group-II aristaless-related protein family whose members are expressed primarily in the central and/or peripheral nervous system. This gene is thought to be involved in CNS development. Mutations in this gene cause X-linked mental retardation and epilepsy.

  • Synonyms

    ARX;aristaless related homeobox

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • HEK293T
  • E.coli
  • His
  • GST
  • Myc&DDK
  • His&Fc&Avi

    Involved Pathway

    ARX involved in several pathways and played different roles in them. We selected most pathways ARX participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ARX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    ARX has several biochemical functions, for example, DNA binding,RNA polymerase II distal enhancer sequence-specific DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARX itself. We selected most functions ARX had, and list some proteins which have the same functions with ARX. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription factor activity, sequence-specific DNA binding TFDP3,SPDEF,OVOL1,PLAGL2,ZNF202,FOXA3,FOXP3,SOX9A,ZNF496,ZNF444
    transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding PAX4,ZBTB16,BACH1,BACH2,MSC,PROP1,GZF1
    RNA polymerase II distal enhancer sequence-specific DNA binding POU4F1,MSC,RXRB,GATA2,H3F3A,RELA,NR5A1,PROP1,ARID3B,NFE2L1
    DNA binding ZNF558,HMBOX1A,Rhox5,AHR2,MAFBA,PCGF6,RARB,TBX4,MKXA,CREB3L3A
    sequence-specific DNA binding FOXI3B,ZC3H8,HOXA3,TLX3,FOXO1B,HOXA7,RX2,ESR2A,SHOX,LHX8A
    chromatin binding CHD7,SSBP1,ATAD2B,BEND6,HMGB1,MSL1,WACA,CAPNS2,PRDM11,CNBPA

    Interacting Protein

    ARX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARX here. Most of them are supplied by our site. Hope this information will be useful for your research of ARX.

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