ARPC2
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Official Full Name
actin related protein 2/3 complex, subunit 2, 34kDa -
Overview
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. -
Synonyms
ARPC2;actin related protein 2/3 complex, subunit 2, 34kDa;actin related protein 2/3 complex, subunit 2 (34 kD);actin-related protein 2/3 complex subunit 2;ARC34;p34 Arc;arp2/3 complex 34 kDa subunit;ARP2/3 protein complex subunit 34;PRO2446;p34-Arc;PNAS-139
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Rhesus macaque
- Porcine
- Mouse
- E.coli
- Mammalian Cells
- E.Coli/Yeast
- Wheat Germ
- HEK293
- Brain
- In Vitro Cell Free System
- Human Cells
- His
- GST
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
ARPC2 involved in several pathways and played different roles in them. We selected most pathways ARPC2 participated on our site, such as Axon guidance,B Cell Receptor Signaling Pathway,Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | TRPC3,DUSP2,IL17RD,COL4A3,NTN1A,RASGRP4,CEBPB,TRIO,MARK3,MEF2AA |
| EPH-Ephrin signaling | AP2M1,AP2S1,KALRNB,EPHB3A,CLTB,EPHA10,KALRN,EFNB1,EFNA1B,EPHA2 |
| Axon guidance | EPHB4,GNAI1,COL4A4,RHOA,RHOB,KDR,SEMA3D,SCN8A,PLXNB2,SPRED3 |
| B Cell Receptor Signaling Pathway | DUSP4,CDK7,MAPK1,INPP5D,ARPC1B,MAPK3,CDK4, Cd79b,PTPN18,RASGRP3 |
| Bacterial invasion of epithelial cells | WAS,FN1,BCAR1,PIK3CG,CRK,SEPT12,CDC42,ARPC1B,ELMO3,SEPT11 |
| Endocytosis | ARFGEF1,PLD2,ASAP2B,RAB11FIP1,BF1,ERBB3,CHMP5B,ITCH,DNM1B,GIT2 |
| EPHB-mediated forward signaling | ARPC1A,CFL1,EPHB4B,ARPC5,EPHB4A,EFNB2A,ACTR3,EFNB1,ARPC1B,EFNB3 |
| CDC42 signaling events | ARPC1B,CFL1,PAK4,BAIAP2,ACTR2,CTNNA1,ARPC3,CDC42BPA,IQGAP3,TNK2 |
Protein Function
ARPC2 has several biochemical functions, for example, AP-1 adaptor complex binding,Arp2/3 complex binding,contributes_to actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPC2 itself. We selected most functions ARPC2 had, and list some proteins which have the same functions with ARPC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DTX3L,PBX2,CACNA1SB,ICA1,MAP4,RHOA,CREBBP,GP9,IFT27,FAM46B |
| structural constituent of cytoskeleton | SPTAN1,CYLC1,TLN2A,BKJ,ARPC3,EPB41L3,ACTR2,ARPC4,TUBA1L2,ARPC5 |
| kinesin binding | SPAG9A,KIFAP3B,SNCA,TOR1A,KCNC1,SPAG9,PPIAL4A,KLC3,KIAA1279,SERPINB1A |
| AP-1 adaptor complex binding | RAB32,RAB38,AP1AR |
| contributes_to actin filament binding | ACTR3,MYH9,ARPC3,ACTR2,MYH10,ARPC4,ARPC5,ARPC1B |
| Arp2/3 complex binding | GMFB,WHAMM,SNX9,HAND2,CORO1B,GMFG,PICK1 |
Interacting Protein
ARPC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPC2.
CORO1B;VCL;VCL;HLA-B;Wasf1;ACTR3B;TRAF6;q7ard3_yerpe;tdh;MYH9;IQGAP1;CAPZA2;Tpm1;Actb;ACTR2;PPP1CB
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Q&As
The recombinant ARPC2 protein is a modified version of the natural ARPC2 protein, produced through genetic engineering techniques. ARPC2 is a subunit of the ARP2/3 protein complex, which plays a critical role in regulating actin cytoskeletal dynamics. The recombinant ARPC2 protein is typically designed for research purposes and is often used as a tool to study the function and interactions of the ARP2/3 complex. It is generated by introducing the genetic sequence of ARPC2 into a suitable expression system, such as bacteria, yeast, or mammalian cells, that can produce large quantities of the protein. The recombinant ARPC2 protein possesses similar structural and functional characteristics as the native ARPC2 protein. It typically retains the ability to interact with other subunits of the ARP2/3 complex and facilitates the formation of branched actin networks. This essential property allows researchers to investigate the mechanisms underlying actin polymerization and cytoskeletal remodeling in various biological processes. Moreover, the recombinant ARPC2 protein can be tagged with specific markers, such as fluorescent tags or affinity tags, to enable easy detection, purification, and visualization. This versatility enhances the utility of the protein in experimental studies. Overall, the recombinant ARPC2 protein serves as a valuable tool for understanding the cellular processes governed by the ARP2/3 complex and provides insights into its involvement in various physiological and pathological conditions. Our routine QC of ARPC2 protein includes BCA, SDS-PAGE, Western Blot, and Endotoxin detection. Here below are the optional services, case to case. Activity Test; HPLC; SEC; Protein Biotinylation; Protein labeling/conjugation.