ARPC1B
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Official Full Name
actin related protein 2/3 complex, subunit 1B, 41kDa -
Overview
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. -
Synonyms
ARPC1B;actin related protein 2/3 complex, subunit 1B, 41kDa;actin related protein 2/3 complex, subunit 1B (41 kD);actin-related protein 2/3 complex subunit 1B;actin related protein 2/3 complex;subunit 1A (41 kD);ARC41;ARP2/3 protein complex subunit
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- Human Cells
- Mammalian cells
- His
- GST
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
ARPC1B involved in several pathways and played different roles in them. We selected most pathways ARPC1B participated on our site, such as Axon guidance,B Cell Receptor Signaling Pathway,Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPC1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| B Cell Receptor Signaling Pathway | FOS,PIK3CD,BLK,PPP3CC,NFATC2,PDK2B,CRK,CARD11,PIK3CG,CD81 |
| Axon guidance | EFNA3,ITGB3A,RHOA,EPHB2,CDK5R1B,KRAS,PAQR3B,PPP3CB,SCN3B,MARK3 |
| Bacterial invasion of epithelial cells | PIK3CB,RHOA,PTK2,WAS,DNM2,WASF1,CBLB,ACTG1,CTNNA1,CRKL |
| EPHB-mediated forward signaling | EPHB4B,EFNB2,KALRNB,EPHB3A,ITSN1,ACTR3,ARPC5,ACTR2B,EFNB1,ARPC2 |
| Developmental Biology | ADAM23,MED15,RND1L,GDF1,CLTC,EFNA1,PEA15,SALL4,ARPC1A,EPHB3A |
| Endocytosis | CLTCB,CCR5,ASAP2,CYTH1A,ADRB3B,RNF41,SNX6,ARF6B,ARAP3,ARAP2 |
| EPH-Ephrin signaling | CFL1,EPHB4B,EFNA1,EFNB2,EFNA2A,KALRN,EPHA2,ARPC5,EFNA1B,KALRNB |
| CDC42 signaling events | ACTR2,CTNNA1,CDC42BPA,IQGAP3,ARPC5,ARPC2,EPS8,CFL1,ARPC3,ARPC4 |
Protein Function
ARPC1B has several biochemical functions, for example, contributes_to actin filament binding,structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPC1B itself. We selected most functions ARPC1B had, and list some proteins which have the same functions with ARPC1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural constituent of cytoskeleton | COX4I2,TUBA8L3,TUBB1,NEFH,TUBG1,ACTL7A,BKJ,TUBA8L2,ARPC5,SPTBN2 |
| contributes_to actin filament binding | ACTR2,MYH10,ARPC2,ARPC3,ARPC4,ACTR3,MYH9,ARPC5 |
Interacting Protein
ARPC1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPC1B here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPC1B.
WAS;WASL;SRPK2;ACTR3B;q81y32_bacan;q81yf9_bacan;Cenpe;MYO1C;Kif3c;Itga5;FLNA;CDK2;MYH9;CRK;CAPZA2;Tpm1
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References
- Jin, LJ; Wu, ZR; et al. Identifying gene expression profile of spinal cord injury in rat by bioinformatics strategy. MOLECULAR BIOLOGY REPORTS 41:3169-3177(2014).
- Rauhala, HE; Teppo, S; et al. Silencing of the ARP2/3 Complex Disturbs Pancreatic Cancer Cell Migration. ANTICANCER RESEARCH 33:45-52(2013).
