ARHGEF18
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Official Full Name
Rho/Rac guanine nucleotide exchange factor (GEF) 18 -
Overview
Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
ARHGEF18;Rho/Rac guanine nucleotide exchange factor (GEF) 18;rho guanine nucleotide exchange factor 18;KIAA0521;MGC15913;P114 RhoGEF;Rho specific guanine nucleotide exchange factor p114;SA-RhoGEF
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- HEK293
- GST
- His
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ARHGEF18-9836H | Recombinant Human ARHGEF18, GST-tagged | E.coli | Human | GST | 1-89a.a. | |
| ARHGEF18-1893M | Recombinant Mouse ARHGEF18 Protein | Mammalian Cells | Mouse | His |
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| ARHGEF18-783H | Recombinant Human ARHGEF18 protein, GST-tagged | Wheat Germ | Human | GST |
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| ARHGEF18-1149HF | Recombinant Full Length Human ARHGEF18 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 89 amino acids |
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| ARHGEF18-1214H | Recombinant Human ARHGEF18 Protein (159-551 aa), GST-tagged | E.coli | Human | GST | 159-551 aa |
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| ARHGEF18-694M | Recombinant Mouse ARHGEF18 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| ARHGEF18-694M-B | Recombinant Mouse ARHGEF18 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ARHGEF18 involved in several pathways and played different roles in them. We selected most pathways ARHGEF18 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE,G alpha (12/13) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR downstream signaling | UTS2,TAS2R13,RAMP1,S1PR1,PTH,FPR-RS6,CCR3,GNA13,SOUL4,PTHRP2 |
| NRAGE signals death through JNK | ARHGEF3,AATF,NET1,ARHGEF17,ECT2,ARHGEF9,PLEKHG2,ARHGEF1A,ARHGEF18A,FGD4 |
| G alpha (12/13) signalling events | KALRN,ARHGEF3,MCF2L,NET1,ARHGEF1B,ARHGEF1A,OBSCN,KALRNB,RHOC,FGD4A |
| Rho GTPase cycle | FGD2,ARHGEF18A,ARHGAP12B,ARHGEF1A,ARHGEF3,TAGAP1,RHOF,MCF2L,RHOT1B,STARD13 |
| Regulation of RhoA activity | OBSCN,ARHGEF10,ARHGEF25,FARP1,ABR,ECT2,NET1,MYO9B,AKAP13,ARHGEF10L |
| Signal Transduction | DLK1,ASH2L,RNF41,PRICKLE1,FAM13B,UTS2,RBP3,OR52J3,RCA2.1,LINGO1B |
| Signaling by GPCR | EMR3,RGR,PLEKHG2,RGS12,RGS20,GPR37B,OR4D2,CCL35.2,PROKR1,RGS7 |
| Cell death signalling via NRAGE, NRIF and NADE | ARHGEF9,TIAM2,ARHGAP4A,OBSCN,ECT2,ITSN1,ARHGEF3,FGD2,ITGB3BP,BCL2L11 |
Protein Function
ARHGEF18 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF18 itself. We selected most functions ARHGEF18 had, and list some proteins which have the same functions with ARHGEF18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rho guanyl-nucleotide exchange factor activity | ARHGEF17,AKAP13,RASGRF2B,VAV3,ARHGEF7A,ABR,TRIO,ARHGEF11,ARHGEF19,FLJ20184 |
| guanyl-nucleotide exchange factor activity | DOCK1,TBXAS1,PCP2,RALGPS1,FGD5,SH2D3CB,VAV3,ARFGEF1,DENND4B,KNDC1 |
Interacting Protein
ARHGEF18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF18 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF18.
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