APRT
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Official Full Name
adenine phosphoribosyltransferase -
Overview
Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
APRT;adenine phosphoribosyltransferase;AMP;AMP diphosphorylase;AMP pyrophosphorylase;APT_HUMAN;DKFZp686D13177;MGC125856;MGC125857;MGC129961;Transphosphoribosidase
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cell
- HEK293
- E.Coli or Yeast
- Wheat Germ
- In Vitro Cell Free System
- HEK293T
- Mamanlian cells
- GST
- His
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
Involved Pathway
APRT involved in several pathways and played different roles in them. We selected most pathways APRT participated on our site, such as Purine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with APRT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Metabolic pathways | DCTPP1,MAT2AB,FBP1B,PLA2G1B,LAP3,UGT1A6B,GCNT4A,PANK1,G6PC3,HIBADH |
Purine metabolism | NME4,NT5C1AA,PRPS1A,CECR1A,ADKA,IMPDH2,AMPD3B,POLE4,XDH,GMPR2 |
Protein Function
APRT has several biochemical functions, for example, AMP binding,adenine binding,adenine phosphoribosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APRT itself. We selected most functions APRT had, and list some proteins which have the same functions with APRT. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
AMP binding | PYGL,PYGM,CYB5R3,ACSS2,PRPS2,PRKAG1,PRPS1,PRKAG2,ACSS1,FBP1 |
Interacting Protein
APRT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APRT here. Most of them are supplied by our site. Hope this information will be useful for your research of APRT.
GH1;MCC;VHL;IKBKE;FTSJ1;TRAF6;MLH1;VCAM1
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References
- Zarella-Boitz, JM; Rager, N; et al. Subcellular localization of adenine and xanthine phosphoribosyltransferases in Leishmania donovani. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 134:43-51(2004).
- Myohanen, S; Baylin, SB; et al. Sequence-specific DNA binding activity of RNA helicase A to the p16(INK4a) promoter. JOURNAL OF BIOLOGICAL CHEMISTRY 276:1634-1642(2001).