APRT

  • Official Full Name

    adenine phosphoribosyltransferase
  • Overview

    Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    APRT;adenine phosphoribosyltransferase;AMP;AMP diphosphorylase;AMP pyrophosphorylase;APT_HUMAN;DKFZp686D13177;MGC125856;MGC125857;MGC129961;Transphosphoribosidase

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • Chicken
  • Rat
  • E.coli
  • Mammalian Cell
  • HEK293
  • E.Coli or Yeast
  • Wheat Germ
  • In Vitro Cell Free System
  • HEK293T
  • Mamanlian cells
  • GST
  • His
  • Myc&DDK
  • Non
  • His&Fc&Avi
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
APRT-1830H Recombinant Human APRT protein, GST-tagged E.coli Human GST 1-180 aa
APRT-10937Z Recombinant Zebrafish APRT Mammalian Cell Zebrafish His
APRT-132H Recombinant Human APRT protein, MYC/DDK-tagged HEK293 Human Myc&DDK
APRT-1939H Recombinant Human Adenine phosphoribosyltransferase E.coli Human Non
APRT-20H Recombinant Human APRT protein, His-tagged E.coli Human His 195aa(including fusion tag)
Aprt-3152M Recombinant Mouse Aprt, His-tagged E.Coli or Yeast Mouse His 180
APRT-5028C Recombinant Chicken APRT Mammalian Cell Chicken His
APRT-591H Recombinant Human APRT protein, His-tagged E.coli Human His Met1~Glu180
APRT-729H Recombinant Human APRT protein, GST-tagged Wheat Germ Human GST
APRT-733R Recombinant Rat APRT Protein Mammalian Cell Rat His
APRT-102HCL Recombinant Human APRT cell lysate Human Non
APRT-0592H Recombinant Human APRT Protein (Met1-Glu180), N-His-tagged E.coli Human His Met1-Glu180
APRT-1154HF Recombinant Full Length Human APRT Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 180 amino acids
Aprt-1669M Recombinant Mouse Aprt Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
APRT-389R Recombinant Rat APRT Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
APRT-389R-B Recombinant Rat APRT Protein Pre-coupled Magnetic Beads HEK293 Rat
APRT-6499H Recombinant Human APRT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
APRT-8029HFL Recombinant Full Length Human APRT protein, Flag-tagged Mamanlian cells Human Flag Full L.

    Involved Pathway

    APRT involved in several pathways and played different roles in them. We selected most pathways APRT participated on our site, such as Purine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with APRT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolic pathways DCTPP1,MAT2AB,FBP1B,PLA2G1B,LAP3,UGT1A6B,GCNT4A,PANK1,G6PC3,HIBADH
    Purine metabolism NME4,NT5C1AA,PRPS1A,CECR1A,ADKA,IMPDH2,AMPD3B,POLE4,XDH,GMPR2

    Protein Function

    APRT has several biochemical functions, for example, AMP binding,adenine binding,adenine phosphoribosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APRT itself. We selected most functions APRT had, and list some proteins which have the same functions with APRT. You can find most of the proteins on our site.

    Function Related Protein
    AMP binding PYGL,PYGM,CYB5R3,ACSS2,PRPS2,PRKAG1,PRPS1,PRKAG2,ACSS1,FBP1

    Interacting Protein

    APRT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APRT here. Most of them are supplied by our site. Hope this information will be useful for your research of APRT.

    GH1;MCC;VHL;IKBKE;FTSJ1;TRAF6;MLH1;VCAM1

    Resources

    References

    • Zarella-Boitz, JM; Rager, N; et al. Subcellular localization of adenine and xanthine phosphoribosyltransferases in Leishmania donovani. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 134:43-51(2004).
    • Myohanen, S; Baylin, SB; et al. Sequence-specific DNA binding activity of RNA helicase A to the p16(INK4a) promoter. JOURNAL OF BIOLOGICAL CHEMISTRY 276:1634-1642(2001).

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