APPL2
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Official Full Name
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 -
Overview
APPL2 is an isoform of APPL1 with 54% identity in their protein sequences. APPL2 has a role in cell proliferation and embryonic development. Recently, it was shown that APPL2 regulates FSH signaling and acts as a negative regulator in adiponectin signalin -
Synonyms
APPL2;adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2;DCC-interacting protein 13-beta;DIP13B;FLJ10659;DIP13 beta;adapter protein containing PH domain, PTB domain and leucine zipper motif 2
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Insect Cell
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- Non
- His
- GST
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| APPL2-1002H | Recombinant Human APPL2 | Insect Cell | Human | Non |
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| APPL2-1003H | Recombinant Human APPL2, His-tagged | E.coli | Human | His |
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| APPL2-28348TH | Recombinant Human APPL2, His-tagged | E.coli | Human | His | Full L. 2-665 a.a. |
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| APPL2-6803Z | Recombinant Zebrafish APPL2 | Mammalian Cell | Zebrafish | His |
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| APPL2-726H | Recombinant Human APPL2 protein, GST-tagged | Wheat Germ | Human | GST |
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| APPL2-8771HCL | Recombinant Human APPL2 293 Cell Lysate | HEK293 | Human | Non |
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| APPL2-1231HF | Recombinant Full Length Human APPL2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 664 amino acids |
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| Appl2-1668M | Recombinant Mouse Appl2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| APPL2-28350TH | Recombinant Human APPL2 | Human | Non | Full L. 1-644 a.a. |
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| APPL2-4331H | Recombinant Human APPL2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
APPL2 involved in several pathways and played different roles in them. We selected most pathways APPL2 participated on our site, such as EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with APPL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| EGFR1 Signaling Pathway | RGS16,TNK2,PITPNAA,CEBPB,PTPN12,REPS2,STXBP1A,ABI1B,RALBP1,KLF11 |
Protein Function
APPL2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APPL2 itself. We selected most functions APPL2 had, and list some proteins which have the same functions with APPL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NABP1,TRIP12,ZNF502,RND3,FAM9A,PPIH,BEGAIN,CASKIN1,MOS,SMAGP |
Interacting Protein
APPL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APPL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APPL2.
APPL1;SUV39H2;RAB22A;MAPRE3;RAB5C
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References
- Cheng, KKY; Lam, KSL; et al. TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt. BIOCHEMICAL JOURNAL 455:207-216(2013).
- King, GJ; Stockli, J; et al. Membrane Curvature Protein Exhibits Interdomain Flexibility and Binds a Small GTPase. JOURNAL OF BIOLOGICAL CHEMISTRY 287:40996-41006(2012).
