APOBEC1
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Official Full Name
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 -
Overview
This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs. -
Synonyms
APOBEC1;apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1;C->U-editing enzyme APOBEC-1;APOBEC 1;BEDP;CDAR1;HEPR;apolipoprotein B mRNA-editing enzyme 1;apolipoprotein B mRNA editing enzyme complex-1
Recombinant Proteins
- Mouse
- Human
- Rat
- Mammalian Cell
- Wheat Germ
- HEK293
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| APOBEC1-1785M | Recombinant Mouse APOBEC1 Protein | Mammalian Cell | Mouse | His |
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| APOBEC1-695H | Recombinant Human APOBEC1 protein, GST-tagged | Wheat Germ | Human | GST |
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| APOBEC1-721R | Recombinant Rat APOBEC1 Protein | Mammalian Cell | Rat | His |
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| APOBEC1-8786HCL | Recombinant Human APOBEC1 293 Cell Lysate | HEK293 | Human | Non |
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| APOBEC1-26872TH | Recombinant Human APOBEC1 | Wheat Germ | Human | Non | 100 amino acids |
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| APOBEC1-377R | Recombinant Rat APOBEC1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| APOBEC1-377R-B | Recombinant Rat APOBEC1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| APOBEC1-631M | Recombinant Mouse APOBEC1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| APOBEC1-631M-B | Recombinant Mouse APOBEC1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
APOBEC1 involved in several pathways and played different roles in them. We selected most pathways APOBEC1 participated on our site, such as Formation of the Editosome,Gene Expression,mRNA Editing, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOBEC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA Editing: C to U Conversion | A1CF |
| mRNA Editing | ADARB1,ADARB1A,A1CF |
| Formation of the Editosome | A1CF |
| Gene Expression | ZNF615,ZNF461,RRAGA,IGF2BP2,EEF1E1,ZNF614,GTF3C5,WDR77,MTERF,ZNF254 |
Protein Function
APOBEC1 has several biochemical functions, for example, AU-rich element binding,RNA binding,cytidine deaminase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APOBEC1 itself. We selected most functions APOBEC1 had, and list some proteins which have the same functions with APOBEC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SGK3,ACE2,PRAC,SHC3,PTPRG,C4orf26,UBE2O,MAPK8IP2,NSF,RIC8A |
| cytidine deaminase activity | APOBEC3F,AICDA,CDA,APOBEC3H,APOBEC2,APOBEC3G,WBP2NL |
| RNA binding | YY1,NCBP1,SNRPE,BOLL,ATXN2,RPL18,RPL22,EIF1AXA,CPEB3,U2AF1L4 |
| AU-rich element binding | ZFP36L1,DND1,EXOSC7,NUDT21,HNRNPA0,ELAVL3,ELAVL1,CPSF5,ZFP36L3,EXOSC4 |
| zinc ion binding | CRIP2,ZNF638,EHMT2,ADAMTS15A,AGBL4,GRIN2A,MMP26,RFPL3,RORCA,ADH7 |
Interacting Protein
APOBEC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOBEC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOBEC1.
Resources
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References
- Burns, MB; Temiz, NA; et al. Evidence for APOBEC3B mutagenesis in multiple human cancers. NATURE GENETICS 45:977-+(2013).
- Rathore, A; Carpenter, MA; et al. The Local Dinucleotide Preference of APOBEC3G Can Be Altered from 5 '-CC to 5 '-TC by a Single Amino Acid Substitution. JOURNAL OF MOLECULAR BIOLOGY 425:4442-4454(2013).
