APOA4
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Official Full Name
apolipoprotein A-IV -
Overview
Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008] -
Synonyms
APOA4;apolipoprotein A-IV;apo-AIV;apoA-IV;apolipoprotein A4
Recombinant Proteins
- Human
- Mouse
- Cattle
- Pig
- Chicken
- Rat
- E.coli
- Mammalian Cells
- HEK293
- E.Coli/Yeast
- Wheat Germ
- In Vitro Cell Free System
- Yeast
- Human Plasma
- GST
- His
- His&T7
- GST&His
- His&S
- Non
- DDK&Myc
- His&SUMO
- Avi&Fc&His
Involved Pathway
APOA4 involved in several pathways and played different roles in them. We selected most pathways APOA4 participated on our site, such as Fat digestion and absorption,Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vitamin digestion and absorption | SLC5A6,SLC46A1,TCN2,CUBN,PNLIP,FOLH1,GIF,LMBRD1,SCARB1,BTD |
| Fat digestion and absorption | PLA2G2A,PNLIPRP2,PPAP2C,PLA2G10,DGAT2,MTTP,AGPAT2,PLA2G3,FABP2,ACAT2 |
Protein Function
APOA4 has several biochemical functions, for example, antioxidant activity,cholesterol binding,cholesterol transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APOA4 itself. We selected most functions APOA4 had, and list some proteins which have the same functions with APOA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylcholine binding | GPR12,APOC1,CETP,PCTP,APOA4B.1,VPS24,APOA1A,APOA5,APOA4B.2,RPE65 |
| lipid binding | BPIFA5,APOEB,FABP9,MARK2,PTGS1,STARD6,HDLBP,TRIP10,LPAR2,RBP2B |
| cholesterol transporter activity | APOE,ABCA1,ABCG4B,APOA4A,ABCA13,ABCA1B,APOEA,APOEB,APOB,APOA1 |
| copper ion binding | DCT,P2RX2,LOXL1,SLC11A2,DBH,CP,LOX,HEPHL1,LOXL3B,PRNP |
| lipid transporter activity | APOA2,VTG1,MTTP,RFT1,APOA1A,CETP,APOM,VTG6,VTG2,APOD |
| phosphatidylcholine-sterol O-acyltransferase activator activity | APOEA,APOA4B.2,APOA1,APOA4A,APOC1,APOA1A,APOA4B.1,APOE,APOEB,APOA2 |
| antioxidant activity | SELS,APOE,PRDX5,SEPW1,PRDX6,FABP1,HP,TRP53INP1,MT3,PRDX2 |
| cholesterol binding | SCP2,APOE,OSBPL10,APOEB,APOA4B.1,APOA2,APOC3,NR1H3,APOA5,ABCA1 |
| protein homodimerization activity | OLIG2,PRDX4,PDCD6IP,MCL1A,CLIC6,ODC1,ASNSD1,TSC2,TAP1,TREX1 |
Interacting Protein
APOA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOA4.
NR1D1;d-mannose;g6pc_human_gene;ALB
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References
- Tokuhara, D; Nochi, T; et al. Specific Expression of Apolipoprotein A-IV in the Follicle-Associated Epithelium of the Small Intestine. DIGESTIVE DISEASES AND SCIENCES 59:2682-2692(2014).
- Zhao, HH; Yang, F; et al. Label Free Proteome Analysis of Plasma from Unstable Angina with Blood Stasis Syndrome Patients. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 31:285-292(2010).
