APEX2

  • Official Full Name

    APEX nuclease (apurinic/apyrimidinic endonuclease) 2

  • Overview

    Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5 to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER).

  • Synonyms

    APEX2;APEX nuclease (apurinic/apyrimidinic endonuclease) 2;DNA-(apurinic or apyrimidinic site) lyase 2;APE2;APEXL2;XTH2;APEX nuclease 2;AP endonuclease 2;AP endonuclease XTH2;APEX nuclease-like 2;apurinic-apyrimidinic endonuclease 2;DNA-apurini

Recombinant Proteins

  • Zebrafish
  • Rhesus macaque
  • Human
  • Mouse
  • Mammalian Cell
  • Mammalian cells
  • HEK293T
  • HEK293
  • His
  • Non
  • Flag
  • Myc&DDK
  • His&Fc&Avi

    Involved Pathway

    APEX2 involved in several pathways and played different roles in them. We selected most pathways APEX2 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with APEX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Base excision repair UNGA,mutY,POLD1,APEX1,SMUG1,POLD2,POLE,MBD4,NEIL3,MPG

    Protein Function

    APEX2 has several biochemical functions, for example, DNA binding,DNA-(apurinic or apyrimidinic site) lyase activity,double-stranded DNA 3-5 exodeoxyribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APEX2 itself. We selected most functions APEX2 had, and list some proteins which have the same functions with APEX2. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding HES7,NR5A1B,KHSRP,DDX3Y,CEBPG,SIX3B,DNAJC1,TBX3A,HOMEZA,ZNF800
    double-stranded DNA 3-5 exodeoxyribonuclease activity APEX1
    zinc ion binding RUNX1,RLIM,ZCCHC8,RARB,MEX3C,CLIP1,UNK,MARCH3,DTX3L,ZNF257
    DNA-(apurinic or apyrimidinic site) lyase activity HMGA1A,HMGA2,HMGA1B,HMGA1-RS1,NTHL1,ALKBH1,APLF,NEIL3,NEIL1,HMGA1

    Interacting Protein

    APEX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APEX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APEX2.

    UBA1;UBE2N;UBE2V1;Map3k1;TRIM37;EFEMP2;TRAF2;CALCOCO2;CCDC85B;HOOK2;NINL;Pcna

    Resources

    References

    • Yui, N; Yoshioka, H; et al. The DNA Repair Enzyme Apurinic/Apyrimidinic Endonuclease (Apex Nuclease) 2 Has the Potential to Protect against Down-Regulation of Chondrocyte Activity in Osteoarthritis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 15:14921-14934(2014).
    • Demple, B; DeMott, MS; et al. Dynamics and diversions in base excision DNA repair of oxidized abasic lesions. ONCOGENE 21:8926-8934(2002).

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