APBA1
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Official Full Name
amyloid beta (A4) precursor protein-binding, family A, member 1 -
Overview
component of multimeric complex containing Munc18-1 and syntaxin; may mediate synaptic vesicle docking/fusion -
Synonyms
APBA1;amyloid beta (A4) precursor protein-binding, family A, member 1;MINT1;amyloid beta A4 precursor protein-binding family A member 1;D9S411E;X11;mint-1;adapter protein X11alpha;adaptor protein X11alpha;neuron-specific X11 protein;neuronal mun
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Apba1-3434R | Recombinant Rat Apba1, His-tagged | E.Coli or Yeast | Rat | His | 839 |
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| APBA1-666H | Recombinant Human APBA1 protein, GST-tagged | Wheat Germ | Human | GST |
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| APBA1-707R | Recombinant Rat APBA1 Protein | Mammalian Cell | Rat | His |
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| APBA1-1077HF | Recombinant Full Length Human APBA1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 837 amino acids |
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| APBA1-363R | Recombinant Rat APBA1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| APBA1-363R-B | Recombinant Rat APBA1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
APBA1 involved in several pathways and played different roles in them. We selected most pathways APBA1 participated on our site, such as Dopamine Neurotransmitter Release Cycle,Neuronal System,Neurotransmitter Release Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with APBA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transmission across Chemical Synapses | SYN2,SLC1A7B,CACNB4B,SNAP25A,CPLX2L,SLC1A2B,SLC1A3B,RAB3AB,ARL6IP5A,SLC17A7A |
| Neurotransmitter Release Cycle | GLS2B,SLC17A7A,LIN7A,SLC1A7A,PPFIA4,RERG,SLC6A11,SLC1A7B,SLC1A2A,SYN1 |
| Neuronal System | DLG1L,KCNH6A,SLC1A2B,RERG,PANX1A,MYO6,KCNJ1A.4,KCNV1,ARL6IP5B,KCNK10B |
| Dopamine Neurotransmitter Release Cycle | SYN2,RERG,CPLX1,UNC13B,CCDC167,LIN7A,PPFIA4,SYN1,PPFIA2,LIN7C |
Protein Function
APBA1 has several biochemical functions, for example, PDZ domain binding,beta-amyloid binding,phosphatidylinositol-4,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APBA1 itself. We selected most functions APBA1 had, and list some proteins which have the same functions with APBA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-amyloid binding | BCHE,MAPK8IP2,CST3,LDLRAP1,APOEA,BACE2,APOA1,APBB2,CHRNA7,LDLRAD3 |
| PDZ domain binding | SLC22A12,KIDINS220,KIDINS220B,SLC9A3,F11R,ATP2B1B,LIN7C,LIN7B,USHBP1,GRASP |
| protein binding | PPP2R1B,VPS72,VPS25,NPRL2,BRD7,ZNF747,PTH2R,FHL3,PVRL2,RPS26 |
| phosphatidylinositol-4,5-bisphosphate binding | STXBP6,SCIN,EXOC1,KCNJ2,TTPA,RAG2,MAPKAP1,PFN1,SLC9A1,SYT1 |
| protein complex binding | RAD18,VHLL,CDK2,AP2A2,ERCC6,INS2,PFKP,ING2,BCAP31,RRAS |
Interacting Protein
APBA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APBA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APBA1.
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References
- Nensa, FM; Neumann, MHD; et al. Amyloid Beta A4 Precursor Protein-binding Family B Member 1 (FE65) Interactomics Revealed Synaptic Vesicle Glycoprotein 2A (SV2A) and Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 (SERCA2) as New Binding Proteins in the Human Brain. MOLECULAR & CELLULAR PROTEOMICS 13:475-488(2014).
- Csiszar, A; Tucsek, Z; et al. Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in beta-amyloid generation and Alzheimer's disease. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 305:H1120-H1130(2013).
