ANO6
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Official Full Name
anoctamin 6 -
Overview
This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ANO6;anoctamin 6;TMEM16F, transmembrane protein 16F;anoctamin-6;DKFZp313M0720;transmembrane protein 16F;SCTS;BDPLT7;TMEM16F;MGC104751
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ANO6-9683H | Recombinant Human ANO6, GST-tagged | E.coli | Human | GST | 1-294a.a. | |
| ANO6-340H | Recombinant Human ANO6 Protein, His-tagged | E.coli | Human | His | Ala744~Asn824 | |
| Ano6-5556M | Recombinant Mouse Ano6 Protein (Ala745-Asn825), C-Fc tagged | Mammalian cells | Mouse | Fc | Ala745-Asn825 |
|
| Ano6-5557M | Recombinant Mouse Ano6 Protein (Ala318-Asn398), C-His tagged | E.coli | Mouse | His | Ala318-Asn398 |
|
| Ano6-5558M | Recombinant Mouse Ano6 Protein (Ala745-Asn825), C-His tagged | Mammalian cells | Mouse | His | Ala745-Asn825 |
|
Involved Pathway
ANO6 involved in several pathways and played different roles in them. We selected most pathways ANO6 participated on our site, such as Ion channel transport,Stimuli-sensing channels,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANO6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transmembrane transport of small molecules | SLC15A2,ATP7B,MIPA,ABCG2D,RHBG,SLC20A1A,RHCGA,SLC12A1,SLC39A1,MRS2 |
| Stimuli-sensing channels | CLCN7,SLC9B2,CLCN1A,ANO4,TRPM4A,TRPC4B,ANO10,CLCN4,CLIC2,TTYH1 |
| Ion channel transport | FXYD3,TTYH3,TTYH2,TRPA1A,TRPM1A,ANO7,TTYH1,ANO10,CLCN5,FXYD7 |
Protein Function
ANO6 has several biochemical functions, for example, calcium activated cation channel activity,NOT intracellular calcium activated chloride channel activity,intracellular calcium activated chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ANO6 itself. We selected most functions ANO6 had, and list some proteins which have the same functions with ANO6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | CBS,HOGA1,CEBPB,UXS1,C9orf142,ACTN3,E2F8,ASCL1,ARID3A,NUDT21 |
| protein binding | SPERT,G6PD,S100A12,COPS5,NKX2-1,TLK2,EEF1G,ATMIN,KCNG3,CDK20 |
| phospholipid scramblase activity | PLSCR2,ANO4,PLSCR3A,PLSCR3B,Ano3,ANO7,PLSCR4,ANO9,PLSCR3,PLSCR1 |
| intracellular calcium activated chloride channel activity | ANO2,TTYH3,ANO4,NMUR2,ANO8,CLCA1,CLCA2,ANO7,CLCA4,ANO9 |
| voltage-gated chloride channel activity | CLCNKA,CLCN2,CLCN1A,CLCN5,CLCN1,CLCN4-2,CLCN3,CLCN7,CLCN6,CLCNK |
| calcium activated cation channel activity | ANO10,PKD2L1,TRPM4,TRPM4C,CALHM1,CATSPER1,TRPM5,TMEM63C,CATSPER2,TRPM4A |
| NOT intracellular calcium activated chloride channel activity | ANO9,ANO10,ANO5,Ano3,ANO7,ANO8 |
| voltage-gated ion channel activity | KCNJ1A.4,CLCN3,TMEM109,KCNJ2A,KCNK16,CLIC1,KCNK7,CACNA1DA,KCNJ1A.5,SCN12AA |
Interacting Protein
ANO6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANO6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANO6.
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