ANAPC11

  • Official Full Name

    anaphase promoting complex subunit 11

  • Overview

    Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

  • Synonyms

    ANAPC11;anaphase promoting complex subunit 11;APC11;Apc11p;MGC882;HSPC214;Anaphase-promoting complex subunit 11;Cyclosome subunit 11;Hepatocellular carcinoma-associated RING finger protein;APC11 anaphase promoting complex subunit 11 homolog;anaphase promoting complex subunit 11 (yeast APC11 homolog)

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • HEK293T
  • His
  • GST
  • Non
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
ANAPC11-9635H Recombinant Human ANAPC11, His-tagged E.coli Human His 1-196a.a.
ANAPC11-010H Recombinant Human ANAPC11 Protein, His-tagged E.coli Human His Full L.
ANAPC11-318R Recombinant Rhesus monkey ANAPC11 Protein, His-tagged Mammalian Cell Rhesus macaque His
ANAPC11-542H Recombinant Human ANAPC11 protein, GST-tagged Wheat Germ Human GST
ANAPC11-5685Z Recombinant Zebrafish ANAPC11 Mammalian Cell Zebrafish His
ANAPC11-8868HCL Recombinant Human ANAPC11 293 Cell Lysate HEK293 Human Non
ANAPC11-8869HCL Recombinant Human ANAPC11 293 Cell Lysate HEK293 Human Non
ANAPC11-8870HCL Recombinant Human ANAPC11 293 Cell Lysate HEK293 Human Non
ANAPC11-1287HF Recombinant Full Length Human ANAPC11 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 54 amino acids
ANAPC11-146R Recombinant Rhesus Macaque ANAPC11 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
ANAPC11-146R-B Recombinant Rhesus Macaque ANAPC11 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Anapc11-1620M Recombinant Mouse Anapc11 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK

    Involved Pathway

    ANAPC11 involved in several pathways and played different roles in them. We selected most pathways ANAPC11 participated on our site, such as Cell cycle,Oocyte meiosis,Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANAPC11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Progesterone-mediated oocyte maturation INS1,CDK1,CPEB4,ANAPC4,CDC16,CPEB1A,MAD2L1,INSB,CDC25B,CCNB2
    Oocyte meiosis PPP2CB,PRKACAA,IGF1R,CALM2,RPS6KA3A,YWHABB,CCNB2,CCNE2,SLK,BTRC
    Cell cycle CDC25B,CHEK2,CCNB2,BUB1B,ARPP19A,PMF1,TSGA14,CDK6,YWHAE,CCNE1
    HTLV-I infection PDGFRB,HLA-A,MAP3K14,TP53INP1,PIK3R2,BUB3,ANAPC2,KRAS,TGFB2,TBPL1
    Ubiquitin mediated proteolysis UBE2F,MGRN1A,SYVN1,CBL,UBE2O,UBE4A,TRIM32,UBE1Y1,SIAH2L,SOCS1

    Protein Function

    ANAPC11 has several biochemical functions, for example, cullin family protein binding,ubiquitin protein ligase activity,contributes_to ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ANAPC11 itself. We selected most functions ANAPC11 had, and list some proteins which have the same functions with ANAPC11. You can find most of the proteins on our site.

    Function Related Protein
    zinc ion binding KPNB1,SIRT6,SAMHD1,MLL5,GATAD2A,RNF220A,RFPL4,TRIM27,NEIL3,MMP3
    ubiquitin-ubiquitin ligase activity STUB1,UBE2K,UBE4B,UBOX5,PRPF19,AMFR,RBX1,PPIL2
    cullin family protein binding TCHP,DCUN1D3,DCUN1D2A,DCUN1D1,KCTD17,RBX1,DCUN1D5,DCUN1D4,CCDC22,DCUN1D2
    ubiquitin protein ligase activity MED31,TRIM6,RNF121,ASB4,FBXO30,ZSWIM2,RNF115,TRIM2,UBE2V2,CCNC
    contributes_to ubiquitin-protein transferase activity KLHL18,BACH1A,KLHL12,KLHL33,KLHL13,FBXL15,FBXL3,KLHL9,CUL3,KBTBD12

    Interacting Protein

    ANAPC11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANAPC11 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANAPC11.

    CDC20;Cdc23;Cdc16;MAK;ZAP70;UBE2U;TRIM65;RNF111;MLKL;NKD2;CAPN11;CDC16

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