ANAPC10
-
Official Full Name
anaphase promoting complex subunit 10 -
Overview
ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is;essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the;anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM;123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 (PubMed;11524682)). -
Synonyms
ANAPC10;anaphase promoting complex subunit 10;anaphase-promoting complex subunit 10;APC10;DKFZP564L0562;DOC1;cyclosome subunit 10
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- His
- GST
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
ANAPC10 involved in several pathways and played different roles in them. We selected most pathways ANAPC10 participated on our site, such as APC-Cdc20 mediated degradation of Nek2A,APC/C-mediated degradation of cell cycle proteins,APC/C:Cdc20 mediated degradation of Cyclin B, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANAPC10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | PSMD14,PSMD5,PSMD10,PSMD9,PSMA8,UBE2C,PSME3,AURKB |
| APC/C:Cdc20 mediated degradation of Cyclin B | UBE2C |
| APC/C:Cdc20 mediated degradation of mitotic proteins | PSMD5,PSMD9,PSME3,UBE2C,PSMD14,PSMD10,NEK2,PSMA8 |
| APC-Cdc20 mediated degradation of Nek2A | NEK2,UBE2C |
| APC/C:Cdc20 mediated degradation of Securin | PSME3,PSMD9,UBE2C,PSMA8,PSMD14,PSMD5,PSMD10 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | PSMA8,NEK2,PSMD10,PSME3,PSMD5,PSMD9,UBE2C,PSMD14 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | PSMD5,NEK2,PSME3,PSMD10,UBE2C,PSMD9,PSMA8,PSMD14 |
| APC/C-mediated degradation of cell cycle proteins | PSME3,PSMD9,CDK2,PSMD14,PSMA8,AURKB,PSMD5,NEK2,PSMD10,UBE2C |
Protein Function
ANAPC10 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ANAPC10 itself. We selected most functions ANAPC10 had, and list some proteins which have the same functions with ANAPC10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
ANAPC10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANAPC10 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANAPC10.
CDC16;Cdc23;Cdc16;Cdc26;CDC23;ANAPC16;Cdc20;Bub1b;MAPK8IP2;PTBP3
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