ANAPC1
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Official Full Name
anaphase promoting complex subunit 1 -
Overview
ANAPC1 is 1 of at least 10 subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle. -
Synonyms
ANAPC1;anaphase promoting complex subunit 1;anaphase-promoting complex subunit 1;APC1;MCPR;TSG24;cyclosome subunit 1;mitotic checkpoint regulator;testis-specific gene 24 protein;anaphase-promoting complex 1 (meiotic checkpoint regulator)
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ANAPC1-9633H | Recombinant Human ANAPC1, His-tagged | E.coli | Human | His | C-term-349a.a. | |
| ANAPC1-1619M | Recombinant Mouse ANAPC1 Protein | Mammalian Cell | Mouse | His |
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| Anapc1-3448M | Recombinant Mouse Anapc1, His-tagged | E.Coli or Yeast | Mouse | His | 1944 |
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| ANAPC1-540H | Recombinant Human ANAPC1 protein, GST-tagged | Wheat Germ | Human | GST |
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| ANAPC1-519M | Recombinant Mouse ANAPC1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ANAPC1-519M-B | Recombinant Mouse ANAPC1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ANAPC1 involved in several pathways and played different roles in them. We selected most pathways ANAPC1 participated on our site, such as Cell cycle,Oocyte meiosis,Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANAPC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oocyte meiosis | PPP3CA,ITPR3,CDC20,PPP3R2,CDK1,IGF1RA,CPEB1B,PPP1CAA,CCNE2,CAMK2G1 |
| Ubiquitin mediated proteolysis | SIAH1,UBA3,UBE2D1,UBE2R2,UBE2M,CDC23,FBXO2,PRP19,UBE2L3,UBE2Q1 |
| HTLV-I infection | MAP2K4,ZFP36,TBPL2,HLA-B,XBP1,NFKB1,PPP3CB,PPP3CC,FZD5,PIK3CB |
| Cell cycle | ARPP19,CDKN2A,SMAD3A,ANAPC5,RNF168,MAPRE1,GORASP2,NUMA1,YWHABA,RAD9A |
| Progesterone-mediated oocyte maturation | MAD2L1,MAD1L1,PPP1R2P9,BUB1,MAPK8B,CDC25C,RPS6KA3B,PIK3R3,FZR1A,PRKACB |
Protein Function
ANAPC1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ANAPC1 itself. We selected most functions ANAPC1 had, and list some proteins which have the same functions with ANAPC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
ANAPC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANAPC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANAPC1.
CDC16;Cdc23;Cdc16;Cdc26;Anapc16;Cdc20;Bub1b
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References
- Ho, AW; Garg, AV; et al. The Anaphase-Promoting Complex Protein 5 (AnapC5) Associates with A20 and Inhibits IL-17-Mediated Signal Transduction. PLOS ONE 8:-(2013).
- Holzmann, J; Fuchs, J; et al. Lesson from the Stoichiometry Determination of the Cohesin Complex: A Short Protease Mediated Elution Increases the Recovery from Cross-Linked Antibody-Conjugated Beads. JOURNAL OF PROTEOME RESEARCH 10:780-789(2011).
