AMPD1
-
Official Full Name
adenosine monophosphate deaminase 1 -
Overview
Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. -
Synonyms
AMPD1;adenosine monophosphate deaminase 1;adenosine monophosphate deaminase 1 (isoform M);AMP deaminase 1;AMPD isoform M;MAD;MADA;skeletal muscle AMPD;AMPD;myoadenylate deaminase;adenosine monophosphate deaminase-1 (muscle)
Recombinant Proteins
- Zebrafish
- Human
- Rat
- Mouse
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- HEK293T Cells
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
AMPD1 involved in several pathways and played different roles in them. We selected most pathways AMPD1 participated on our site, such as Purine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AMPD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | AMPD3B,POLR2J2,POLR3G,POLR1C,POLD1,PDE6D,POLD2,AK2,PNPT1,NUDT2 |
| Metabolic pathways | SLC33A1,ALLC,GBA2,CDS1,TKTL1,SDHC,PPAP2C,UAP1,ALG3,DGKD |
Protein Function
AMPD1 has several biochemical functions, for example, AMP deaminase activity,metal ion binding,myosin heavy chain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AMPD1 itself. We selected most functions AMPD1 had, and list some proteins which have the same functions with AMPD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ANKMY1,FGD6,KLF17,BNC2,ADAMTS16,ZNF566,MGAT4C,TPP1,PRKCD,STK32C |
| AMP deaminase activity | AMPD3,AMPD3B,AMPD2 |
| myosin heavy chain binding | MYL2,PDLIM2,CORO1A,MYL9,MYL12B,MYBPC3 |
Interacting Protein
AMPD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMPD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AMPD1.
C1QTNF9;GABARAP;MAP1LC3B;GABARAPL1;MAP1LC3A
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