ALG11
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Official Full Name
ALG11 asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast) [ Homo sapiens ] -
Overview
This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP). This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19. -
Synonyms
AI849156;alg11;ALG11_HUMAN;Asparagine-linked glycosylation 11;Asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast);Asparagine-linked glycosylation protein 11 homolog;AW492253;B230397C21;GT8;KIAA0266;OTTMUSP00000022781;RGD1564725
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- Debaryomyces hansenii
- Yarrowia lipolytica
- zebrafish
- Dictyostelium Discoideum
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Arabidopsis thaliana
- Mus musculus
- Candida albicans
- Xenopus laevis
- Pongo Abelii
- Kluyveromyces lactis
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- His&Fc&Avi
Involved Pathway
ALG11 involved in several pathways and played different roles in them. We selected most pathways ALG11 participated on our site, such as N-Glycan biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALG11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | NDUFB3,ATP5IB,RDH10A,PNMT,GMPPAA,ALPI.2,ENPP7,GATC,PCYT1BA,IMPA1 |
| N-Glycan biosynthesis | MAN1A1,ALG14,ALG10,RABGNT1,MAN1C1,MGAT2,MGAT4B,MGAT1A,ALG6,ALG2 |
Protein Function
ALG11 has several biochemical functions, for example, GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALG11 itself. We selected most functions ALG11 had, and list some proteins which have the same functions with ALG11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
ALG11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALG11 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALG11.
UBE2G2
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