ALDH8A1
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Official Full Name
aldehyde dehydrogenase 8 family, member A1 -
Overview
This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene. -
Synonyms
ALDH8A1;aldehyde dehydrogenase 8 family, member A1;aldehyde dehydrogenase family 8 member A1;ALDH12;aldehyde dehydrogenase 12;aldehyde dehydrogenase family protein;DJ352A20.2;MGC138650;DKFZp779D2315
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- E. coli
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- N-GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ALDH8A1 involved in several pathways and played different roles in them. We selected most pathways ALDH8A1 participated on our site, such as RA biosynthesis pathway,Signal Transduction,Signaling by Retinoic Acid, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH8A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | NMT1B,OXGR1,RBP2A,ARHGAP24,HECW1B,RGR,SHRPRBCK1R,GPR37L1,PTH,INSL3 |
| RA biosynthesis pathway | RDH14B,CYP26A1,DHRS9,ADH8A,RDH14,CRABP1B,RDH10,ADH8B,RDH13,AKR1C21 |
| Signaling by Retinoic Acid | AKR1C6,DHRS3,CRABP2,RDH14A,FABP11B,PDK4,PDK3,CRABP1A,CRABP1B,CRABP2A |
Protein Function
ALDH8A1 has several biochemical functions, for example, aldehyde dehydrogenase (NAD) activity,retinal dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH8A1 itself. We selected most functions ALDH8A1 had, and list some proteins which have the same functions with ALDH8A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aldehyde dehydrogenase (NAD) activity | ALDH16A1,ALDH9A1,Aldh1a7,ALDH7A1,ALDH3B2,ALDH6A1,ALDH3A2A,ALDH1A1,ALDH9A1B,ALDH3A2 |
| retinal dehydrogenase activity | AKR1B10,AKR1C6,AKR1C4,ALDH1A3,Aldh1a7,AKR1B8,AKR1C3,ALDH1A1 |
Interacting Protein
ALDH8A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH8A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH8A1.
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