ALAD
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Official Full Name
aminolevulinate dehydratase -
Overview
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. -
Synonyms
ALAD;aminolevulinate dehydratase;aminolevulinate, delta , dehydratase;delta-aminolevulinic acid dehydratase;ALADH;PBGS;porphobilinogen synthase;MGC5057;OTTMUSP00000009377;RP11-10I9.1;ALADR;Delta aminolevulinic acid dehydratase;Lv;OTTMUSP00000009376;RP24-189G18.9;aminolevulinate, delta-, dehydratase
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Cynomolgus
- Chicken
- Rat
- Mammalian Cells
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- HEK293
- His
- GST
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
ALAD involved in several pathways and played different roles in them. We selected most pathways ALAD participated on our site, such as Porphyrin and chlorophyll metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALAD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | PCYT1AA,GLB1,ADSL,ACSL4A,ATP6AP1,CRYL1,PLA2G2D,PTGES3B,ACSL3,HMBSA |
| Porphyrin and chlorophyll metabolism | HMOX2A,HMBSA,UGT1A6,UROS,HCCSB,UGT2B7,P22,CPOX,EPRS,HCCSA.1 |
Protein Function
ALAD has several biochemical functions, for example, catalytic activity,identical protein binding,lead ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALAD itself. We selected most functions ALAD had, and list some proteins which have the same functions with ALAD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | MIB2,ING5B,ZNF638,ZGLP1,TTF2,NR2F1A,ZDHHC14,TRIM46B,ZDHHC3A,TRIM33 |
| identical protein binding | CBX3,PCBD1,APIP,FBLN1,NEFL,LZTFL1,BCHE,TRP53,SMN2,TRA@ |
| catalytic activity | DDAH2,EML5,IMPDH1A,PHYKPL,ETNPPL,SLC3A2,PCXB,UQCRC2A,GOT2A,CKMT1 |
Interacting Protein
ALAD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALAD here. Most of them are supplied by our site. Hope this information will be useful for your research of ALAD.
Alad;15-deoxy-delta(12,14
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References
- Bardag-Gorce, F; French, SW; et al. Delta-aminolevulinic dehydratase is a proteasome interacting protein. EXPERIMENTAL AND MOLECULAR PATHOLOGY 91:485-489(2011).
- Varadharajan, S; Sagar, BKC; et al. Localization of ferrochelatase in Plasmodium falciparum. BIOCHEMICAL JOURNAL 384:429-436(2004).
