AKTIP
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Official Full Name
AKT interacting protein -
Overview
The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKBs regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. -
Synonyms
AKTIP;AKT interacting protein;FTS, fused toes (mouse) homolog , fused toes homolog (mouse);AKT-interacting protein;FLJ13258;AKTIP_HUMAN;FT 1;FT1;Fused toes homolog;Fused toes protein homolog;OTTHUMP00000164256;FTS
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- Cynomolgus
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
- His&SUMO
Involved Pathway
AKTIP involved in several pathways and played different roles in them. We selected most pathways AKTIP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AKTIP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
AKTIP has several biochemical functions, for example, protein binding,ubiquitin protein ligase activity,ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKTIP itself. We selected most functions AKTIP had, and list some proteins which have the same functions with AKTIP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SRPK2,Chrng,EIF2B3,MED9,AAGAB,SOCS7,GALR2,PSMC6,EXD1,C22orf29 |
| ubiquitin protein ligase binding | LTBR,TXNIP,PCBP2,UBE2KA,HDAC6,H2-AB1,DAXX,IKBKE,NFKBIA,CUL3B |
| ubiquitin protein ligase activity | HERC5,RNF126,ARIH1L,AMFR,TRIM2,MYLIP,G2E3,RNF34,CDK8,LTN1 |
Interacting Protein
AKTIP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKTIP here. Most of them are supplied by our site. Hope this information will be useful for your research of AKTIP.
HOOK1;HOOK2;4504555;HDLBP;DCTN1;PDS5A;TIMM50;RASGRF2;MAP3K7;ASS1;NEB;RPA1;ACTN2;TRIM23
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References
- Lv, SZ; Dai, CX; et al. Cell Surface Protein C23 Affects EGF-EGFR Induced Activation of ERK and PI3K-AKT Pathways. JOURNAL OF MOLECULAR NEUROSCIENCE 55:519-524(2015).
- Chaudhary, P; Thamake, SI; et al. Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies. BRITISH JOURNAL OF CANCER 111:2328-2341(2014).
