AKR1D1
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Official Full Name
aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) -
Overview
The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet. -
Synonyms
AKR1D1;aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase);SRD5B1;3-oxo-5-beta-steroid 4-dehydrogenase;3o5bred;AK1D1_HUMAN;aldo keto reductase family 1 member D1 (delta 4 3 ketosteroid 5 beta reductase);Aldo keto reductase family 1 member D1;Aldo-keto reductase family 1 member D1;CBAS2;Delta(4) 3 ketosteroid 5 beta reductase;Delta(4) 3 oxosteroid 5 beta reductase;Delta(4)-3-ketosteroid 5-beta-reductase;Delta(4)-3-oxosteroid 5-beta-reductase;steroid 5 beta reductasebeta polypeptide 1 (3 oxo 5 beta steroid delta 4 dehydrogenase beta 1);steroid 5 beta reductase;OTTHUMP00000208643;OTTHUMP00000208644;OTTHUMP00000208645;steroid-5-beta-reductase, beta polypeptide 1 (3-oxo-5 beta-steroid delta 4-dehydro
Recombinant Proteins
- Mouse
- Human
- Chicken
- Rat
- Mammalian Cell
- Human
- E.coli
- Wheat Germ
- HEK293
- E. coli
- In Vitro Cell Free System
- HEK293T
- His
- Non
- GST
- N-GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
AKR1D1 involved in several pathways and played different roles in them. We selected most pathways AKR1D1 participated on our site, such as Primary bile acid biosynthesis,Steroid hormone biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1D1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Primary bile acid biosynthesis | SCP2,BRSK2,SCP2A,CYP7B1,AKR1C4,CYP46A1.2,CH25HL1.2,CH25H,BAAT,ACOX2 |
| Metabolic pathways | TKT,NDUFB2,MTMR7,GDA,COX4I2,CAD,GGT5,NADSYN1,HYAL4,SLC27A5 |
| Steroid hormone biosynthesis | UGT1A6,COMTB,PPP1R2,CYP2D9,CYP3A7,SULT2ST3,HSD17B12B,SULT1E1,STS,HSD3B2 |
Protein Function
AKR1D1 has several biochemical functions, for example, delta4-3-oxosteroid 5beta-reductase activity,steroid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1D1 itself. We selected most functions AKR1D1 had, and list some proteins which have the same functions with AKR1D1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| delta4-3-oxosteroid 5beta-reductase activity | AKR1C3 |
| steroid binding | PGRMC2,CYP21A2,NR3C1,CYP21A1,PAQR7B,PGRMC1,PAQR5,ESRRB,PAQR8,HSD3B4 |
Interacting Protein
AKR1D1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1D1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1D1.
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References
- Yang, F; He, YQ; et al. All-trans retinoic acid regulates hepatic bile acid homeostasis. BIOCHEMICAL PHARMACOLOGY 91:483-489(2014).
- Yanagi, T; Mizuochi, T; et al. Distinguishing primary from secondary Delta(4)-3-oxosteroid 5 beta-reductase (SRD5B1, AKR1D1) deficiency by urinary steroid analysis. CLINICAL ENDOCRINOLOGY 82:346-351(2015).
