AKAP13

  • Official Full Name

    A kinase (PRKA) anchor protein 13

  • Overview

    The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins.

  • Synonyms

    AKAP13;A kinase (PRKA) anchor protein 13;LBC, lymphoid blast crisis oncogene;A-kinase anchor protein 13;AKAP Lbc;ARHGEF13;BRX;c lbc;HA 3;Ht31;PROTO LB;p47;AKAP-13;LBC oncogene;A-kinase anchoring protein;lymphoid blast crisis oncogene;huma
Cat.# Product name Source (Host) Species Tag Protein Length Price
AKAP13-399H Recombinant Human AKAP13 Protein, GST-tagged Wheat Germ Human GST
AKAP13-45HCL Recombinant Human AKAP13 cell lysate Human Non
AKAP13-398H Recombinant Human AKAP13 protein, GST-tagged E.coli Human GST 359-587 aa

    Involved Pathway

    AKAP13 involved in several pathways and played different roles in them. We selected most pathways AKAP13 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE,G Protein Signaling Pathways,G alpha (12/13) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Regulation of RhoA activity DEF6,OBSCN,ARHGEF3,ARHGEF25,ABR,NET1,ARHGEF10,ARHGEF28,MCF2L,ARHGEF18
    Rho GTPase cycle ARHGAP36,ARHGAP8,DEPDC1B,DLC1,RHOJ,ARHGEF3,ARHGAP29,FAM13B,ARHGAP20,ARAP1
    Cell death signalling via NRAGE, NRIF and NADE OBSCN,KALRN,ARHGAP4,ARHGEF18,ARHGEF9,PLEKHG2,FGD4,NET1,FGD4A,MCF2L
    Signal Transduction ARHGAP12B,SH2B3,NPS,TAX1BP1,GPR65,CHN2,ROR1,DLC1,NMT1B,ARHGEF18
    G Protein Signaling Pathways GNB3B,Akap3,GNG13B,AKAP1,AKAP12,KCNJ3,AKAP6,AKAP1B,GNGT2A,GNA13
    G alpha (12/13) signalling events MCF2L,RHOAE,ARHGEF16,ARHGEF1B,KALRN,FGD4,ARHGEF18A,ARHGEF3,RHOGA,RHOC
    GPCR downstream signaling CXCR7B,TAS2R13,PRKCHB,SSTR3,CCL27,CCR9,CXCR6,CXCL13,TRPC7,OR2AP1
    NRAGE signals death through JNK ARHGEF18,MCF2L,FGD2,ARHGEF1A,PLEKHG2,FGD4,AATF,TIAM2,FGD4A,ARHGAP4A

    Protein Function

    AKAP13 has several biochemical functions, for example, Rho GTPase binding,Rho guanyl-nucleotide exchange factor activity,cAMP-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP13 itself. We selected most functions AKAP13 had, and list some proteins which have the same functions with AKAP13. You can find most of the proteins on our site.

    Function Related Protein
    protein binding CFLAR,PPP2R5C,ABI2,FGF12,JUB,EIF2S3,USH1G,SEMA4D,CCDC146,EIF4ENIF1
    Rho guanyl-nucleotide exchange factor activity ARHGEF37,ALS2CL,ARHGEF25,ARHGEF9,ARHGEF7B,ABR,FLJ20184,FARP2,FGD,FGD6
    protein complex scaffold CNOT1,MAGI1,AKAP6,MAP2K2,DISC1,KLHL17,AXIN1,CAPN3,SLC9A1,PKP2
    protein kinase A binding DACT3,NBEA,AKAP7,MYRIP,AKAP4,RARA,Akap3,DACT2,AKAP5,LRRK2
    signal transducer activity PLCD4,TICAM2,TAAR14F,ADORA2AB,PROKR1A,GNA13A,TAAR8B,RHOC,NDFIP1,TRAF2
    metal ion binding DGKQ,ZNF155,MBLAC2,KLF15,PRKCD,CRBN,ARL1,CACNA2D1,GMEB1,ZSWIM4
    cAMP-dependent protein kinase activity PRKACA,PRKACG,PRKX,PRKAA1,PRKAG1,PRKACB
    Rho GTPase binding DAAM1,DOCK9,DOCK10,DIAP1,FLNA,ROCK2B,DAAM1B,DIAPH3,DIAP3,ECT2

    Interacting Protein

    AKAP13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP13 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP13.

    YWHAB;ESR1;YWHAG;TGM2;THRA;Ppara;YWHAZ;BAK1;RANBP2;uvrB;lysU;q7arb9_yerpe

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