AKAP1

  • Official Full Name

    A kinase (PRKA) anchor protein 1

  • Overview

    The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment.

  • Synonyms

    AKAP1;A kinase (PRKA) anchor protein 1;PRKA1;A-kinase anchor protein 1, mitochondrial;AKAP84;AKAP121;AKAP149;D AKAP1;dual specificity A kinase anchoring protein 1;PPP1R43;protein kinase anchoring protein 1;protein phosphatase 1;regulatory subunit 43;S AKAP84;SAKAP84;A kinase anchor protein;AKAP 149;AKAP;DAKAP1;Protein kinase A1;D-AKAP-1;A-kinase anchor protein 149 kDa;protein kinase A anchoring protein 1;spermatid A-kinase anchor protein 84;protein phosphatase 1, regulatory subunit 43;dual-specificity A-kinase anchoring protein 1;D-AKAP1

Recombinant Proteins

  • Mouse
  • Rhesus macaque
  • Rat
  • Human
  • Mammalian Cell
  • E.Coli or Yeast
  • Wheat Germ
  • HEK293
  • E.coli
  • His
  • GST
  • Non
  • His&Fc&Avi

    Involved Pathway

    AKAP1 involved in several pathways and played different roles in them. We selected most pathways AKAP1 participated on our site, such as Factors involved in megakaryocyte development and platelet production,G Protein Signaling Pathways,Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hemostasis KIF5B,PRTN3,NADL1.1,CEACAM6,SRGN,GATA1A,TRPC7,MMRN1,PLEK,KIF22
    Factors involved in megakaryocyte development and platelet production H3F3B.1,KIF5A,KIF4,MGC173646,HBB-Y,KIF5B,DOCK11,MYB,GATA5,MAFGA
    G Protein Signaling Pathways ARHGEF1A,Akap3,AKAP6,GNGT2A,AKAP13,GNA13,AKAP1B,AKAP7,AKAP4,AKAP12B

    Protein Function

    AKAP1 has several biochemical functions, for example, RNA binding,beta-tubulin binding,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP1 itself. We selected most functions AKAP1 had, and list some proteins which have the same functions with AKAP1. You can find most of the proteins on our site.

    Function Related Protein
    protein complex scaffold AKAP9,DISC1,ITSN1,CAPN3,SLC9A3R1,MPP7,HOMER1,MAGI1,CAV1,DLG1
    protein kinase binding FZD5,CD226,SKI,NEK6,GRB7,GPRC5B,DPYSL2,PTPRJ,POLA1,ADCY6
    protein kinase A regulatory subunit binding ACBD3,ARFGEF1,RYR2,AKAP9,PJA2,C2orf88,EZR,AKAP8,AKAP7,AKAP6
    RNA binding RPL7,PATL1,HNRNPL2,HDLBPA,JAKMIP1,DDX51,RPL11,RPS4Y1,EIF2C3,CAPRIN1
    microtubule binding KRIT1,FGF13,ZFP207,SGIP1,APC,RAE1,NEIL2,PLK1,HOOK3,PEX14
    poly(A) RNA binding UTP11L,C14orf21,CORO1A,AKAP8L,ETF1A,UNK,YWHAZ,SRP19,FNDC3B,CPEB2
    protein binding CLCN1,CCDC146,C1orf94,CNOT8,LRRC4B,BNIP1,MMRN2,MC5R,CST5,KRT15
    beta-tubulin binding B4GALT1,PIFO,CASC1,IFT74,SIRT2,ADNP,SNCA,GABARAP,CCT5,TBCD
    protein domain specific binding PLG,TACC1,YWHABA,MITD1,HIST1H4I,YWHAH,FOXA2,ZNF521,STX1B,ABCC2

    Interacting Protein

    AKAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP1.

    PRKAR2A;PRKACA;Siah2;USP7;DYSF;PRKAR1A;p29991-pro_0000037941;MYCBP;3',5'-cyclic amp;2_aha_camp;8-aha-camp

    Resources

    References

    • Sotgia, F; Whitaker-Menezes, D; et al. Mitochondria "fuel" breast cancer metabolism Fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells. CELL CYCLE 11:4390-4401(2012).
    • Reinton, N; Collas, P; et al. Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis. DEVELOPMENTAL BIOLOGY 223:194-204(2000).

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