AK1
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Official Full Name
adenylate kinase 1 -
Overview
Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme. -
Synonyms
AK1;adenylate kinase 1;adenylate kinase isoenzyme 1;AK 1;myokinase;ATP-AMP transphosphorylase 1
Recombinant Proteins
- Chicken
- Rat
- Zebrafish
- Human
- Mouse
- Pig
- Chicken Muscle
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- Non
- His
- GST
- Flag
- Myc&DDK
- His&Fc&Avi
- His&SUMO
Involved Pathway
AK1 involved in several pathways and played different roles in them. We selected most pathways AK1 participated on our site, such as Purine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | AMPD1,POLR3E,NME6,NUDT5,IMPDH1,POLR2H,PDE10A,NUDT2,PKM,POLR2GL |
| Metabolic pathways | HSD17B12,MAT2A,NDUFA4L2,DTYMK,CHKB,MT-ND1,AMPD3,ACADM,PNP,SCP2 |
Protein Function
AK1 has several biochemical functions, for example, ATP binding,adenylate kinase activity,nucleoside diphosphate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AK1 itself. We selected most functions AK1 had, and list some proteins which have the same functions with AK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | NMRK1,DDX47,PPP2R4,CAMK2B1,DYNC1LI1,EPHB4B,ULK2,PIK3C3,ATP7A,SMARCAL1 |
| adenylate kinase activity | AK8,AK5,AK4,AK7,AK2 |
| nucleoside diphosphate kinase activity | AK8,CMPK,NME1,CMPK2,AK4,NME9,NME8,NME3,NME2A,AK5 |
Interacting Protein
AK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AK1.
KMT2C;TERF1;fldB;TINF2;TERF2IP;NBAS;MRE11A;TIA1;OGT;PCF11;CD2BP2;SLC12A2;DECR1;COBLL1;B3GALTL;RAB11FIP2;KDM3B;GEMIN5;CIRH1A
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References
- Xu, ZS; Du, WD; et al. Development of a Protein Biochip to Identify 6 Monoclonal Antibodies Against Subtypes of Recombinant Human Interferons. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES 8:212-218(2010).
- Ravera, S; Musante, L; et al. Expression of adenylate kinase 1 in bovine retinal cytosol. CURRENT EYE RESEARCH 32:249-257(2007).
