AHCYL1
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Official Full Name
adenosylhomocysteinase-like 1 -
Overview
The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. -
Synonyms
AHCYL1;adenosylhomocysteinase-like 1;S adenosylhomocysteine hydrolase like 1;putative adenosylhomocysteinase 2;inositol 1;4;5 trisphosphate receptor binding protein;IRBIT;XPVKONA;adoHcyase 2;DC-expressed AHCY-like molecule;S-adenosyl-L-homocyst
Recombinant Proteins
- Zebrafish
- Chicken
- Rhesus macaque
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
Involved Pathway
AHCYL1 involved in several pathways and played different roles in them. We selected most pathways AHCYL1 participated on our site, such as Adaptive Immune System,Antigen activates B Cell Receptor (BCR) leading to generation of second messengers,C-type lectin receptors (CLRs), which may be useful for your reference. Also, other proteins which involved in the same pathway with AHCYL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DAG and IP3 signaling | ADRBK1,PRKAR1AA |
| DAP12 interactions | SPTBN2,CD300LB,CLEC5A,FGF20A,LAMTOR2,FRS2B,FGF8B,DUSP7,DUSP10,AGO2 |
| Cysteine and methionine metabolism | LDHBA,GSS,MTAP,GOT1,MAT2B,LDHAL6B,AGXT2,GOT2A,DNMT3AA,MDH1 |
| C-type lectin receptors (CLRs) | ITPR2,CLEC4D,UBE2V1,CLEC4A,CREBBP,CLEC6A,CASP8L1,MALT1,IL1B2,TAB1 |
| Adaptive Immune System | CD300LD,UBR2,MICA,RNF111,LILRA1,CMTM2A,LILRB2,ITK,FBXO44,UBE2V1 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | IGLC2,BLK,ITPR2,AKR1C1,STIM1B,IGKC,SRMS,IGKV1-5,IGHM,PIK3AP1 |
| CLEC7A (Dectin-1) signaling | MALT1,CASP8L1,TAB1,UBE2V1,IL1B2 |
Protein Function
AHCYL1 has several biochemical functions, for example, RNA binding,NOT adenosylhomocysteinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AHCYL1 itself. We selected most functions AHCYL1 had, and list some proteins which have the same functions with AHCYL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | IMPDH2,KHNYN,SF1,SRSF10,ZFR,OOEP,PABPN1L,AKAP1B,FBL,DNAJC17 |
| NOT adenosylhomocysteinase activity | AHCYL2 |
| protein binding | ARFRP1,NFKBIB,ACY3,MAPKAPK3,RNF216,UBE2O,SCFD1,PODXL2,INTS7,YIPF3 |
Interacting Protein
AHCYL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AHCYL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AHCYL1.
MEOX2;PSMD9;PPL;SOX30;tat;CDKN2C
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References
- Ando, H; Kawaai, K; et al. IRBIT: A regulator of ion channels and ion transporters. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1843:2195-2204(2014).
- Panagopoulos, I; Brandal, P; et al. Novel CSF1-S100A10 fusion gene and CSF1 transcript identified by RNA sequencing in tenosynovial giant cell tumors. INTERNATIONAL JOURNAL OF ONCOLOGY 44:1425-1432(2014).
