AHCY
-
Official Full Name
adenosylhomocysteinase -
Overview
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
AHCY;adenosylhomocysteinase;S adenosylhomocysteine hydrolase;SAHH;adoHcyase;S-adenosylhomocysteine hydrolase;S-adenosyl-L-homocysteine hydrolase
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Rat
- Zebrafish
- E.coli
- E. coli
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- His
- Non
- GST
- Myc&DDK
- N-His
- Flag
- His&Fc&Avi
- His&SUMO
Involved Pathway
AHCY involved in several pathways and played different roles in them. We selected most pathways AHCY participated on our site, such as Biological oxidations,Cysteine and methionine metabolism,Folate Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AHCY were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of amino acids and derivatives | OAZ3,GLS2B,OAZ1A,PPM1K,DCT,TPH2,SLC25A15B,HIBADHA,AZIN2,CKMT2A |
| Methylation | TPMT.2,AS3MT |
| Cysteine and methionine metabolism | AMD1,LDHA,IL4I1,MTAP,GOT2B,DNMT3AB,CBSA,LDHC,SMS,GOT2A |
| Biological oxidations | FDXR,GLYATL2,SULT1C2,CYP4F11,CYP3A4,UGT1B7,SLC35B3,CYP11A1,CYP2V1,CES1 |
| One Carbon Metabolism | MTHFD2,ST20-MTHFS,MTHFS,MTFMT,ALDH1L1,FTCD |
| Metabolic pathways | COX17,ACACA,FH1,DNMT3AA,QPRT,CDIPT,DNMT4,KMO,CYP2C19,CYP2A4 |
| Metabolism | GRX2,FAAH2B,PAICS,AKR1C2,MAPK1IP1L,SULT1ST6,NUDT18,SLC25A32A,CYP4B1,CKMB |
| Folate Metabolism | ABCA1,SAA2,SAA1,SAA2-SAA4,SAA4 |
Protein Function
AHCY has several biochemical functions, for example, NAD binding,adenosylhomocysteinase activity,adenyl nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AHCY itself. We selected most functions AHCY had, and list some proteins which have the same functions with AHCY. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | SH3GL3,TMEM173,B2M,KLHL7,RAD51,LEPR,STAT6,DAPK2,CLDN4,PAICS |
| NAD binding | GRHPRB,GLYR1,GAPDHS,MDH1,BDH2,HADHA,AOX4,LDHA,SORD,UGDH |
| protein binding | DNER,PRPF6,DDX39A,PCSK2,ABCG8,SRSF5,ACP1,SLC40A1,MEGF6,EPHA7 |
Interacting Protein
AHCY has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AHCY here. Most of them are supplied by our site. Hope this information will be useful for your research of AHCY.
ANKRD40;APPBP2;C1orf50;ORF;Kif1c;EIF1B;BCAR3;MCC;HLA-B;YWHAZ;PAK2;PINX1;TRAF6
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