AGTR2

  • Official Full Name

    angiotensin II receptor, type 2
  • Overview

    The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation.
  • Synonyms

    AGTR2;angiotensin II receptor, type 2;angiotensin receptor 2;type-2 angiotensin II receptor;AT2;MRX88;angiotensin II type-2 receptor;ATGR2

Recombinant Proteins

  • Zebrafish
  • Human
  • Rat
  • Mus musculus
  • Sheep
  • Mammalian Cell
  • Wheat Germ
  • E.coli
  • HEK293
  • E. coli
  • Yeast
  • E.coli expression system
  • His
  • GST
  • His&SUMO
  • Non
  • N-GST
  • His&Flag
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
AGTR2-2130Z Recombinant Zebrafish AGTR2 Mammalian Cell Zebrafish His
AGTR2-30H Recombinant Human AGTR2, GST-tagged Wheat Germ Human GST
AGTR2-33H Recombinant Human AGTR2 protein, His/SUMO-tagged E.coli Human His&SUMO 1-45aa
AGTR2-397H Recombinant Human AGTR2 Mammalian Cell Human His
AGTR2-8969HCL Recombinant Human AGTR2 293 Cell Lysate HEK293 Human Non
ABO-3794H Recombinant Human ABO protein, GST-tagged E. coli Human N-GST 54-354 aa
AGTR2-1058HFL Recombinant Human AGTR2 protein, His&Flag-tagged HEK293 Human His&Flag 1-363 aa
AGTR2-1321R Recombinant Rat AGTR2 Protein (1-45 aa), His-tagged Yeast Rat His 1-45 aa
AGTR2-2445H Recombinant Human AGTR2 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
AGTR2-2445H-B Recombinant Human AGTR2 Protein Pre-coupled Magnetic Beads HEK293 Human
AGTR2-313R Recombinant Rat AGTR2 Protein (1-45 aa), GST-tagged E.coli Rat GST 1-45 aa
RFL-21796MF Recombinant Full Length Mouse Type-2 Angiotensin Ii Receptor(Agtr2) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length (1-363aa)
RFL29720OF Recombinant Full Length Sheep Type-2 Angiotensin Ii Receptor(Agtr2) Protein, His-Tagged E.coli expression system Sheep His Full L. Full Length (1-260)

    Involved Pathway

    AGTR2 involved in several pathways and played different roles in them. We selected most pathways AGTR2 participated on our site, such as ACE Inhibitor Pathway,Adrenergic signaling in cardiomyocytes,Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with AGTR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    G alpha (i) signalling events SSTR3,CCL35.2,LPAR5A,HCAR1-2,ADRA2C,CHRM2,OPN5,TAS2R3,CCR7,SSTR5
    GPCR ligand binding LPAR1,NMS,ADORA2A,S1PR3,MLN,HEBP1,GPR31B,PYYA,TAC1,CXCR7B
    GPCRs, Class A Rhodopsin-like GPR39,ACKR4,DRD4,GPR18,CNR2,FPR-RS4,GPR17,NMUR1,OPN4,GPR6
    Class A/1 (Rhodopsin-like receptors) ADRA2B,NMS,OPN1MW2,PPY,S1PR3,CCL35.1,EDNRAB,GPBAR1,OXGR1A.2,ADRA2C
    Adrenergic signaling in cardiomyocytes CALM2,PPP2R1A,ACTC1B,MAPK14,ADCY8,ADRB2,GNAI3,PRKACAA,PIK3R3B,SCN5A
    ACE Inhibitor Pathway CTSG,ATP6AP2,AGTR1,CMA1,AGT,CYP11B2,ACE
    GPCR downstream signaling CCR3,MLN,RAMP1,OPN1SW1,PYYA,UTS2D,NPS,NPFFR2,OBSCN,SSTR3
    Neuroactive ligand-receptor interaction TAAR13C,TACR1B,GHRHR,GNRHR2,PTAFR,GRM2,F2RL1.2,NMUR2,DRD4B,MAS1

    Protein Function

    AGTR2 has several biochemical functions, for example, angiotensin type II receptor activity,peptide hormone binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGTR2 itself. We selected most functions AGTR2 had, and list some proteins which have the same functions with AGTR2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding STAG3,PCDH18B,YOD1,DRD1,KRTAP13-3,RBM15,DEDD,SEPT9,RELL2,DOK2
    peptide hormone binding GHR,NPR1,GALR2,INHBA,PTH1RA,RXFP2,NPR2,EDNRB,GHRHR,MC4R
    transcription factor binding TRIM11,MLXIPL,MYOD1,FIGLA,PER1,DIP2A,UBN1,SMAD3,NKX3,PAX2
    angiotensin type II receptor activity AGTR1B,CXCR3.2,AGTR1A,APLNRA,APLNRB,AGTR1,RXFP3.2B,AGTRAP,RXFP4
    receptor antagonist activity ADH7,IL18BP,LRPAP1,DKK1,ESR2

    Interacting Protein

    AGTR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGTR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGTR2.

    TIMP3;AGT;AGT

    Resources

    References

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