AGTR2
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Official Full Name
angiotensin II receptor, type 2 -
Overview
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation. -
Synonyms
AGTR2;angiotensin II receptor, type 2;angiotensin receptor 2;type-2 angiotensin II receptor;AT2;MRX88;angiotensin II type-2 receptor;ATGR2
Recombinant Proteins
- Zebrafish
- Human
- Rat
- Mus musculus
- Sheep
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- Yeast
- His
- GST
- SUMO
- Non
- Flag
- Avi
- Fc
Involved Pathway
AGTR2 involved in several pathways and played different roles in them. We selected most pathways AGTR2 participated on our site, such as ACE Inhibitor Pathway,Adrenergic signaling in cardiomyocytes,Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with AGTR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Class A/1 (Rhodopsin-like receptors) | GPR55A,GPBAR1,EDNRAB,OPN4A,CCR1,LPAR5A,CCK,EDNRA,GPR77,AGTR1 |
| ACE Inhibitor Pathway | CYP11B2,CMA1,ACE,ATP6AP2,AGTR1,CTSG,AGT |
| GPCR ligand binding | APLN,CASR,OPN1SW1,PYYA,KISS1,GCGA,CHRM1,RGR,TRH,SST1.1 |
| GPCRs, Class A Rhodopsin-like | GPR65,GPR75,GPR31,CMKLR1,GPR68,OPN1SW,GPR3,GPR50,CX3CR1,GPR27 |
| G alpha (i) signalling events | OPN5,CCR6,SSTR1,NMS,OXGR1A.1,OPN1MW2,ANXA1C,HEBP1,APLNR,OPN1LW |
| Neuroactive ligand-receptor interaction | GNRHR4,HTR1D,MCHR2,HCRTR1,TAAR14E,OPRD1B,TACR1A,TAAR10C,NPFFR1L2,RXFP2 |
| Adrenergic signaling in cardiomyocytes | PIK3CD,PLCB4,CALM3,GNA11A,CREB3L2,ADRA1B,CACNA1C,CREB5,Adcy4,KCNQ1 |
| GPCR downstream signaling | RAMP1,APPB,RAMP2,PMCH,OR2AP1,CXCL13,PRKCHB,ABR,GCGA,NMS |
Protein Function
AGTR2 has several biochemical functions, for example, angiotensin type II receptor activity,peptide hormone binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGTR2 itself. We selected most functions AGTR2 had, and list some proteins which have the same functions with AGTR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FLAD1,RAPGEF4,HOPX,MPHOSPH6,BHLHE40,FOXG1,PROX1,BRD7,AAK1,NEURL1B |
| angiotensin type II receptor activity | AGTR1B,APLNRA,RXFP3.2B,CXCR3.2,AGTR1A,RXFP4,AGTR1,APLNRB,AGTRAP |
| receptor antagonist activity | ADH7,IL18BP,DKK1,LRPAP1,ESR2 |
| peptide hormone binding | GHSR,PTH1R,NPR1,ANXA5,MC4R,GCGR,HCRTR2,RXFP2,GHR,MAS1 |
| transcription factor binding | DRAP1,APBB3,STK36,ZEB1,E2F5,RORA,PURB,HDAC4,PPARGC1B,DNAJA3 |
Interacting Protein
AGTR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGTR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGTR2.
TIMP3;AGT;AGT
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