AGPAT2
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Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) -
Overview
1-acyl-sn-glycerol-3-phosphate acyltransferase beta is an enzyme that in humans is encoded by the AGPAT2 gene. -
Synonyms
AGPAT2;1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta);1-acyl-sn-glycerol-3-phosphate acyltransferase beta;1 acyl sn glycerol 3 phosphate acyltransferase beta;1 acylglycerol 3 phosphate O acyltransferase 2;1 AGP acyltransferase 2;1 AGPAT2;1-acylglycerol-3-phosphate O-acyltransferase 2;1-AGP acyltransferase 2;1-AGPAT 2;Berardinelli Seip congenital lipodystrophy;BSCL;BSCL1;EC 2.3.1.51;LPAAB;LPAAT beta;LPAAT-beta;Lysophosphatidic acid acyltransferase beta;Lysophosphatidic acid acyltransferase-beta;PLCB_HUMAN;AV000834;2510002J07Rik
Recombinant Proteins
- Human
- Zebrafish
- Mus musculus
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
Involved Pathway
AGPAT2 involved in several pathways and played different roles in them. We selected most pathways AGPAT2 participated on our site, such as Adipogenesis,CDP-diacylglycerol biosynthesis,CDP-diacylglycerol biosynthesis I, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGPAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipogenesis | CNTFR,PLIN2,EGR2,CEBPB,NR2F1A,CFD,DDIT3,CDKN1A,BMP3,KLF6 |
| Fat digestion and absorption | DGAT1,SCARB1,PLA2G3,PLA2G12A,FABP2,PLA2G2D,SLC27A4,PLA2G2A,PNLIPRP2,ABCA1 |
| CDP-diacylglycerol biosynthesis | AGPAT6,AGPAT1,GK5,CDS1,GPAT2 |
| Glycerophospholipid biosynthesis | CDIPT,GPAT2,CPNE6,PLD6,PTPMT1,STIL,PLA2G16,PLBD1,AWAT2,DGAT1B |
| CDP-diacylglycerol biosynthesis I | AGPAT1 |
| Fatty acid, triacylglycerol, and ketone body metabolism | THEM5,MED23,SIN3B,TIAM2,PPARGC1B,ACOT11B,MED29,GRHL1,ACOT8,ACOT10 |
| Glycerolipid metabolism | DGKZ,GK,TAE1,AKR1A1,LIPCA,AKR1B1L,LCLAT1,DGKA,LPIN2,Akr1b3 |
| Glycerophospholipid metabolism | AGPAT4,PCYT2,AGPAT1,PLA2G5,ACHE,CDS1,PLD1,LPIN1,PLA2G4F,LPCAT3 |
Protein Function
AGPAT2 has several biochemical functions, for example, 1-acylglycerol-3-phosphate O-acyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AGPAT2 itself. We selected most functions AGPAT2 had, and list some proteins which have the same functions with AGPAT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 1-acylglycerol-3-phosphate O-acyltransferase activity | AGPAT5,AGPAT9,AGPAT4,AGPAT1,LPCAT2,AGPAT9L,LCLAT1,ABHD5,LYCAT,AGPAT3 |
Interacting Protein
AGPAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGPAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGPAT2.
ANKRD28;GMPS;ABCG8;PHRF1;SLC23A2;PHF11
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References
- Sankella, S; Garg, A; et al. Hepatic Gluconeogenesis Is Enhanced by Phosphatidic Acid Which Remains Uninhibited by Insulin in Lipodystrophic Agpat2 Mice*. JOURNAL OF BIOLOGICAL CHEMISTRY 289:4762-4777(2014).
- Agarwal, AK; Garg, A; et al. Enzymatic activity of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 11: upregulated in breast and cervical cancers. JOURNAL OF LIPID RESEARCH 51:2143-2152(2010).
