AGO2

  • Official Full Name

    argonaute RISC catalytic component 2

  • Overview

    This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

  • Synonyms

    AGO2;argonaute RISC catalytic component 2;Q10;EIF2C2;protein argonaute-2;PPD;hAgo2;eIF2C 2;eIF-2C 2;argonaute2;argonaute 2;protein slicer;PAZ Piwi domain protein;eukaryotic translation initiation factor 2C, 2

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • Insect Cell
  • E. coli
  • E.coli
  • HEK293
  • Mammalian Cell
  • HEK293T
  • Yeast
  • Insect Cells
  • His
  • N-His
  • GST
  • Myc&DDK
  • Non
Cat.# Product name Source (Host) Species Tag Protein Length Price
EIF2C2-2180H Active Recombinant Human EIF2C2, His-tagged Insect Cell Human His Met 1-Ala 859
AGO2-2180H Recombinant Human AGO2, His-tagged Insect Cell Human His Met 1-Ala 859
ACSS3-9329H Recombinant Human ACSS3 protein, His-tagged E. coli Human N-His 341-686 aa
AGO2-3126H Recombinant Human AGO2 protein, His-tagged E.coli Human His 603-780 aa
AGO2-3693H Recombinant Human AGO2 protein, GST-tagged E.coli Human GST
AGO2-526H Recombinant Human AGO2 Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
AGO2-8477Z Recombinant Zebrafish AGO2 Mammalian Cell Zebrafish His
AGO2-576MCL Recombinant Mouse AGO2 cell lysate Insect Cell Mouse Non
AGO2-714HCL Recombinant Human AGO2 cell lysate Insect Cell Human Non
AGO2-02H Recombinant Human AGO2 Protein E.coli Human
Ago2-1556M Recombinant Mouse Ago2 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
AGO2-1728H Recombinant Human AGO2 Protein (517-818 aa), His-tagged Yeast Human His 517-818 aa
AGO2-2241M Recombinant Mouse AGO2 protein, His-tagged Insect Cells Mouse His Met1-Ala860

    Involved Pathway

    AGO2 involved in several pathways and played different roles in them. We selected most pathways AGO2 participated on our site, such as Adaptive Immune System,Beta-catenin independent WNT signaling,Ca2+ pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System FBXO3,CTSS,HCST,TRAT1,SH3RF1,CD300LG,CD300E,UFL1,TREML1,CYBB
    DAP12 interactions THEM4,RASGRP1,LAMTOR2,CSF2RA,AGO3,HBEGF,CLEC5A,SPTBN1,LCP2A,AHCYL1
    Downstream signaling of activated FGFR1 SPRED2,MARK3,KBTBD7,PAQR3A,WDR83,DUSP2,PAQR3B,PEA15,SPRED3,SPNA1
    Ca2+ pathway AGO3,GNB5,MOV10,AGO1
    Downstream signal transduction KBTBD7,PEBP1,FGF18B,MARK3,DUSP2,THEM4,FRS3,MOV10,DUSP9,PAQR3A
    Beta-catenin independent WNT signaling MOV10,AP2B1,AP2S1,CLTA,AGO1,AGO3,DVL2,AP2M1,ITPR2,CLTB
    DAP12 signaling DUSP6,FGF10B,SPTB,MARK3,DUSP5,DUSP7,FGF20A,DUSP4,DAB2IPB,SPRED1

    Protein Function

    AGO2 has several biochemical functions, for example, RNA 7-methylguanosine cap binding,RNA polymerase II core binding,core promoter binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGO2 itself. We selected most functions AGO2 had, and list some proteins which have the same functions with AGO2. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core binding RECQL5,PAF1,SMYD2,ZFP326,C14orf166,GTF2E1,SMYD2A,CDC73,ZNF326,RPRD1B
    endoribonuclease activity SMG6,RCL1,PLD6,RNASET2,DROSHA,NOB1,RNASEK,TSN,ERN1,RNASEKB
    protein binding ANKS1A,SNRPD1,FAM212A,USE1,LNX2,ALK,HUS1,CXCL10,ELAVL1,ZBED1
    translation initiation factor activity EIF3E,DHX29,EIF4EB,EIF1AXA,EIF1AX,EIF4E3,EIF4E1B,BRF1A,EIF4E1C,EIF4H
    single-stranded RNA binding NXF1,TLR8,EIF2C3,CBX6,POLR2GL,ZFP36,LUZP4,ANXA1,A1CF,CBX4
    siRNA binding TARBP2,TLR9,TLR7,DICER1,MECP2
    metal ion binding SNRNP48,TRIM35-30,HCCS,ZNF254,MYSM1,REST,RBM22,NRAP,PLA2G3,SMAD5
    mRNA binding CPSF6,RBM5,ADARB1,HNRNPAB,SOSTDC1B,ELAVL1,CSTF2T,CLUHA,XPO5,ESRP1
    protein C-terminus binding PPP1R9B,TJP2,YEATS4,DBNL,HIC2,ARL6IP5,CDC37,XRCC5,VGLL1,ECM1

    Interacting Protein

    AGO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGO2.

    DICER1;TNRC6B

    Resources

    References

    • Yang, JCS; Wu, SC; et al. TLR4/NF-kappa B-Responsive MicroRNAs and Their Potential Target Genes: A Mouse Model of Skeletal Muscle Ischemia-Reperfusion Injury. BIOMED RESEARCH INTERNATIONAL :-(2015).
    • Bukong, TN; Momen-Heravi, F; et al. Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90. PLOS PATHOGENS 10:-(2014).

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