AGAP2
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Official Full Name
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 -
Overview
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. -
Synonyms
AGAP2;ArfGAP with GTPase domain, ankyrin repeat and PH domain 2;centaurin, gamma 1 , CENTG1;arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2;cnt-g1;centaurin, gamma 1;phosphoinositide 3-kinase enhancer;phosphatidylinositol 3-kinas
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Zebrafish
- Rat
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- His&Fc&Avi
Involved Pathway
AGAP2 involved in several pathways and played different roles in them. We selected most pathways AGAP2 participated on our site, such as FoxO signaling pathway,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FoxO signaling pathway | GABARAP,IL7R,MAPK1,PIK3R3B,RAF1,GRB2,PRKAB1B,GRM1,CDKN1BB,MAPK11 |
| Endocytosis | TGFBR1A,SMAP2,TGFB2,DNM2B,ARF3,EEA1,MVB12BB,SMAD3A,ZFYVE27,CDC42L |
Protein Function
AGAP2 has several biochemical functions, for example, ATP binding,GTP binding,GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AGAP2 itself. We selected most functions AGAP2 had, and list some proteins which have the same functions with AGAP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol 3-kinase regulator activity | PIK3R3B,KLF4,PIK3R3A,PIK3R1 |
| GTPase activator activity | TBC1D10B,TBC1D10C,LLGL1,GNAQ,PLCB1,TBC1D15,ARHGAP11A,MURC,CDC42EP4A,RGS5A |
| metal ion binding | ATP13A4,GM757,ZUFSP,ZDHHC15A,MECOM,SALL3,ZNF461,CDK5RAP1,MMP25,CLEC7A |
| protein kinase activator activity | MAPK8IP2,NKX3-1,FAM58A,DUSP19,PIK3CA,DBF4B,STK11,GPRC5B,STRADA,NKX3 |
| GTPase activity | GNL3L,RAB7A,RHOT1A,DIRAS1,ARL4C,RAB38,RAB1BB,GTPBP10,DNM2B,NUDT1 |
| nucleotide binding | CLK2A,MAPK14A,HNRNPA0,ROCK2B,MOCS2,BSK146,DGKAA,AKT3A,HHAT,MATR3L |
| ATP binding | ABCA3,RAF1A,DDX17,OAS1B,BCKDK,CCT6A,KIF12,RBKS,KATNA1,C22orf28 |
| GTP binding | EEF1A1B,NOA1,ARL10,GNAQ,EIF2S3,NME1,ARL8,GBP2,RAB8B,LSG1 |
| protein kinase binding | EMP2,SPRED1,SHC3,BCAR1,CALM2,TUBB3,RAB11FIP2,RAB8A,AXIN1,PTPN2 |
Interacting Protein
AGAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGAP2.
Insr;Stat5a;Dcc;Unc5b;Grip1;SNCA;Ywhab
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