AGA
-
Official Full Name
aspartylglucosaminidase -
Overview
Aspartylglucosaminidase is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme. Alternatively spliced transcript variants have been identified. -
Synonyms
AGA;aspartylglucosaminidase;N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase;ASRG;glycosylasparaginase;AGU;Aspartylglucosylamine deaspartylase;Aspartylglycosaminuria;ASPG_HUMAN;GA;Glycosylasparaginase beta chain;N4 (N acetyl beta glucosaminyl) L asparagine amidase;N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase
Recombinant Proteins
- Human
- Chicken
- Cynomolgus
- Rat
- Zebrafish
- Mouse
- HEK293
- Mammalian Cell
- Insect Cell
- Wheat Germ
- Human Cell
- E.coli
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- His&SUMO
Involved Pathway
AGA involved in several pathways and played different roles in them. We selected most pathways AGA participated on our site, such as Integrated Pancreatic Cancer Pathway,L-asparagine degradation III (mammalian),Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Other glycan degradation | NEU3.1,HEXA,HEXDC,MAN2B1,NEU3.4,NEU2,MAN2C1,MAN2B2,NEU1,NEU3.5 |
| Integrated Pancreatic Cancer Pathway | PPP1R13L,TOP1,FKBP1B,NOXA1,IL11,CST3,TOP2A,CASP12,RAPGEF3,CD82 |
| Lysosome | DNASE2B,DNASE2,LAMP3,LAPTM4A,CTSSA,CTNS,CTSO,LITAF,ATP6V1H,PSAP |
Protein Function
AGA has several biochemical functions, for example, N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity,peptidase activity,protein self-association. Some of the functions are cooperated with other proteins, some of the functions could acted by AGA itself. We selected most functions AGA had, and list some proteins which have the same functions with AGA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein self-association | SHANK3,EPB49,AGTR1A,AGTR1B,LDB1,CNTN2,TMEM190,S100A7A,CCDC88C,RSAD2 |
| peptidase activity | CPD,C6AST4,PLAUA,OVCH2,MCPT1,EGFBP2,BMP1B,FURINB,ZRANB1B,DESI2 |
Interacting Protein
AGA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGA here. Most of them are supplied by our site. Hope this information will be useful for your research of AGA.
q81kn9_bacan;ALB
Resources
Related Services
Related Products
References
- Hasan, Z; Atkinson, B; et al. Short Report: Diagnostic Testing for Hemorrhagic Fevers in Pakistan: 2007-2013. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 91:1243-1246(2014).
- Jackson, J; Eaton, W; et al. Gluten sensitivity and relationship to psychiatric symptoms in people with schizophrenia. SCHIZOPHRENIA RESEARCH 159:539-542(2014).
