AFF4
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Official Full Name
AF4/FMR2 family, member 4 -
Overview
The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). -
Synonyms
AFF4;AF4/FMR2 family, member 4;AF4/FMR2 family member 4;AF5Q31;ALL1 fused gene from 5q31;MCEF;ALL1-fused gene from chromosome 5q31 protein;major CDK9 elongation factor-associated protein;MGC75036
Recombinant Proteins
- Human
- Wheat Germ
- Mammalian Cell
- HEK293
- E. coli
- In Vitro Cell Free System
- GST
- His
- Non
- N-His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| AFF4-407H | Recombinant Human AFF4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| AFF4-696H | Recombinant Human AFF4 | Mammalian Cell | Human | His |
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| AFF4-8988HCL | Recombinant Human AFF4 293 Cell Lysate | HEK293 | Human | Non |
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| ABCE1-5743H | Recombinant Human ABCE1 protein, His-tagged | E. coli | Human | N-His | 250-599 aa |
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| AFF4-2439H | Recombinant Human AFF4 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| AFF4-2439H-B | Recombinant Human AFF4 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| AFF4-989HF | Recombinant Full Length Human AFF4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 365 amino acids |
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Involved Pathway
AFF4 involved in several pathways and played different roles in them. We selected most pathways AFF4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AFF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
AFF4 has several biochemical functions, for example, protein binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AFF4 itself. We selected most functions AFF4 had, and list some proteins which have the same functions with AFF4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CEP350,ZNF410,MUTYH,RAD23B,CYGB,MPPED2,ARPC4,SLC35F6,SOX14,ADAM15 |
| transcription factor activity, sequence-specific DNA binding | NR2F6A,TRERF1,HOXB8B,HOMEZ,HOXB8A,HOXB2,SMAD1,RNF4,HIF1A,TCF25 |
Interacting Protein
AFF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AFF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of AFF4.
CDK9;CCNT1;MLLT1
Resources
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References
- Liu, PY; Xiang, YH; et al. Release of Positive Transcription Elongation Factor b(P-TEFb)from 7SK Small Nuclear Ribonucleoprotein ( snRNP) Activates Hexamethylene Bisacetamide- inducible Protein ( HEXIM1) Transcription*. JOURNAL OF BIOLOGICAL CHEMISTRY 289:9918-9925(2014).
- Lu, HS; Li, ZC; et al. AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:E15-E24(2014).
