AFF3
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Official Full Name
AF4/FMR2 family, member 3 -
Overview
This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. -
Synonyms
AFF3;AF4/FMR2 family, member 3;LAF4, lymphoid nuclear protein related to AF4;AF4/FMR2 family member 3;MLLT2 like;protein LAF-4;MLLT2-related protein;lymphoid nuclear protein 4;lymphoid nuclear protein related to AF4;LAF4;MLLT2-like
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| AFF3-3232H | Recombinant Human AFF3, His-tagged | E.Coli or Yeast | Human | His | 1251 |
|
| Aff3-3233M | Recombinant Mouse Aff3, His-tagged | E.Coli or Yeast | Mouse | His | 1254 |
|
Involved Pathway
AFF3 involved in several pathways and played different roles in them. We selected most pathways AFF3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AFF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
AFF3 has several biochemical functions, for example, double-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AFF3 itself. We selected most functions AFF3 had, and list some proteins which have the same functions with AFF3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| double-stranded DNA binding | TP63,MTERFD2,EGFR,KIN,MRE11A,RBMS1,TP53,SATB1,FEV,TRP53 |
Interacting Protein
AFF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AFF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of AFF3.
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References
- Viatte, S; Plant, D; et al. Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients. ANNALS OF THE RHEUMATIC DISEASES 71:1984-1990(2012).
