AFF1
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Official Full Name
AF4/FMR2 family, member 1 -
Overview
Note=A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with MLL/HRX. The result is a rogue activator protein. -
Synonyms
AFF1;AF4/FMR2 family, member 1;AF4;PBM1;MLLT2;AF4/FMR2 family member 1;protein AF-4;proto-oncogene AF4;pre-B-cell monocytic leukemia partner 1;ALL1-fused gene from chromosome 4 protein;myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila);translocated to, 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Aff1-3230M | Recombinant Mouse Aff1, His-tagged | E.Coli or Yeast | Mouse | His | 1216 |
|
| AFF1-405H | Recombinant Human AFF1 Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| AFF1-1732H | Recombinant Human AFF1 protein, His & T7-tagged | E.coli | Human | His&T7 | Met1~Gly183 |
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| AFF1-26446TH | Recombinant Human AFF1 | Wheat Germ | Human | Non | 100 amino acids |
|
Involved Pathway
AFF1 involved in several pathways and played different roles in them. We selected most pathways AFF1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with AFF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | HIST1H3H,MEN1,MPO,ITGB7,HIST2H3A,CCND2,MLF1,BCL2L1,CCNT1,CCNT2 |
Protein Function
AFF1 has several biochemical functions, for example, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AFF1 itself. We selected most functions AFF1 had, and list some proteins which have the same functions with AFF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | RELA,ZFP184,ZNF302,TCF7L2,TAL1,RBPJL,ZSCAN4F,TFEB,TCF7L1A,HOXC5 |
Interacting Protein
AFF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AFF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AFF1.
Resources
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References
- Cen, H; Leng, RX; et al. Association of AFF1 rs340630 and AFF3 rs10865035 polymorphisms with systemic lupus erythematosus in a Chinese population. IMMUNOGENETICS 64:935-938(2012).
- Lu, HS; Li, ZC; et al. AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:E15-E24(2014).
