ADO

  • Official Full Name

    2-aminoethanethiol (cysteamine) dioxygenase

  • Overview

    Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase;(ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to;form hypotaurine (Dominy et al., 2007 (PubMed 17581819)).

  • Synonyms

    ADO;2-aminoethanethiol (cysteamine) dioxygenase;C10orf22, chromosome 10 open reading frame 22;2-aminoethanethiol dioxygenase;cysteamine dioxygenase;FLJ14547;cysteamine (2-aminoethanethiol) dioxygenase (ADO);C10orf22;DKFZp564C046

Recombinant Proteins

  • Mouse
  • Rhesus macaque
  • Human
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Myc&DDK
  • His&Fc&Avi

    Involved Pathway

    ADO involved in several pathways and played different roles in them. We selected most pathways ADO participated on our site, such as Taurine and hypotaurine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Taurine and hypotaurine metabolism CDO1,ADOB,GAD1,GAD2,GGT7,CSAD,GGT1,GGT1A,GGT5,GGT5A
    Metabolic pathways CYP2A12,MTHFS,ADKA,NDUFA9,GALNT9,GLUD1,TSTA3,SGMS1,PHGDH,KL

    Protein Function

    ADO has several biochemical functions, for example, cysteamine dioxygenase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADO itself. We selected most functions ADO had, and list some proteins which have the same functions with ADO. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding GALNS,ZNF558,ZFP879,KDM5BA,DPH3,ZNF100,DMRTA2,MAZ,ALOX5B.2,MEP1A.2

    Interacting Protein

    ADO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADO here. Most of them are supplied by our site. Hope this information will be useful for your research of ADO.

    FYCO1

    Resources

    References

    • Ahmed, S; Sami, A; et al. HER2-directed therapy: current treatment options for HER2-positive breast cancer. BREAST CANCER 22:101-116(2015).
    • Carneiro, BA; Meeks, JJ; et al. Emerging therapeutic targets in bladder cancer. CANCER TREATMENT REVIEWS 41:170-178(2015).

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