ADH1B
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Official Full Name
alcohol dehydrogenase 1B (class I), beta polypeptide -
Overview
The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. -
Synonyms
ADH1B;alcohol dehydrogenase 1B (class I), beta polypeptide;ADH2;alcohol dehydrogenase 1B;ADH beta subunit;ADH1B_HUMAN;alcohol dehydrogenase 2 (class I), beta polypeptide;Alcohol dehydrogenase 2;Alcohol dehydrogenase subunit beta;Aldehyde reductase;DKFZp686C06125;OTTHUMP00000220192;ADH, beta subunit
Recombinant Proteins
- Rhesus macaque
- Cynomolgus
- Human
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- Mammalian cells
- HEK293T
- His
- GST
- Non
- Flag
- His&SUMO
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ADH1B involved in several pathways and played different roles in them. We selected most pathways ADH1B participated on our site, such as Biological oxidations,Chemical carcinogenesis,Drug metabolism - cytochrome P450, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty Acid Omega Oxidation | ADH1C,ADH7,CYP2A6,CYP1A1,CYP2D6,CYP2E1,ADH1A,ADH4,CYP4A11,ADH6 |
| Fatty acid degradation | CPT1C,ACSL1B,ACOX3,ALDH3A2,ACSL5,ACSL4B,ACADL,ACSBG1,EHHADH,ADH7 |
| Metabolic pathways | NT5C1BA,DAO,NNMT,CYP2P6,MTMR14,COMTA,IDS,BCO1,MCAT,ACSS2 |
| Biological oxidations | PAOX,SLC26A2,SLC26A1,CES1,ABHD14B,UGT1B2,CYP2AD2,FAM84B,Sult2a2,FDXR |
| Ethanol oxidation | ADH6,ADH1A,ADH8B,ADH7,ADH4,ADH1C,ADH8A,ADH5 |
| Chemical carcinogenesis | CYP2C9,ADH7,GSTT2,CYP2C39,GSTA1,ADH1,PTGS2,GSTP2,ALDH3A1,UGT1A2 |
| Glycolysis / Gluconeogenesis | ADH2-2,PGM1,AKR1A1,ENO1A,G6PC,PCK2,ALDOA,LDHA,ENO1B,MINPP1 |
| Drug metabolism - cytochrome P450 | CYP3A5,CYP2C19,ADH7,GSTK1,ADH5,CYP2C8,CYP2A6,GSTO2,CYP2C9,ADH2-2 |
Protein Function
ADH1B has several biochemical functions, for example, alcohol dehydrogenase activity, zinc-dependent,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH1B itself. We selected most functions ADH1B had, and list some proteins which have the same functions with ADH1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | PDLIM3A,USP51,KMT2E,NR2E3,HE1B,S100A12,Adam6,CA13,YAF2,DYTN |
| alcohol dehydrogenase activity, zinc-dependent | ADH4,ADH1A,ADH7 |
Interacting Protein
ADH1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH1B here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH1B.
SERPINA3;PML;GNB2L1;PDE4DIP;yvcN;ykwC;IRAK3
Resources
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References
- Yokoyama, A; Mizukami, T; et al. Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 and Liver Cirrhosis, Chronic Calcific Pancreatitis, Diabetes Mellitus, and Hypertension Among Japanese Alcoholic Men. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 37:1391-1401(2013).
- Chiang, CP; Wu, CW; et al. Expression Pattern, Ethanol-Metabolizing Activities, and Cellular Localization of Alcohol and Aldehyde Dehydrogenases in Human Small Intestine. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 36:2047-2058(2012).
