ADD1
-
Official Full Name
adducin 1 (alpha) -
Overview
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. -
Synonyms
ADD1;adducin 1 (alpha);alpha-adducin;erythrocyte adducin alpha subunit;ADDA;MGC3339;MGC44427
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Chicken
- Zebrafish
- Rat
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- HEK293T
- E.coli
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ADD1 involved in several pathways and played different roles in them. We selected most pathways ADD1 participated on our site, such as Apoptosis,Apoptotic cleavage of cellular proteins,Apoptotic execution phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Programmed Cell Death | DAPK1,STK24A,DSG3,DIABLOB,STK26,PLECA,PANK1A,CASP6L2,BMX,STK24 |
| Metabolism of proteins | BCHE,ARSK,TIMM21,TMED2,CST3,SPON1A,TOMM7,FKBP14,MIA3,PFDN2 |
| Apoptosis | CDK5RAP2,CASP3B,MAP3K14,DFFB,DIABLO,PIK3CG,BIRC8,PIK3R3,DIABLOB,NFKBIAB |
| Apoptotic cleavage of cellular proteins | LMNB1,DBNLA,CASP6L1,DBNLB,STK24,PKP1,DSG2,CTNNB2,CASP8L1,DBNL |
| Caspase-mediated cleavage of cytoskeletal proteins | CASP6L2,SPNA2,CASP6L1,DBNLB,DBNLA,PLECA,PLEC,DBNL,VIML,GAS2 |
| Miscellaneous transport and binding events | ANKHA,MRS2,NIPA1,ADD2,ANKH,AZGP1,PIP,MAGT1,CTNS,ADD3A |
| IRE1alpha activates chaperones | SEC61B,PREB,SERP1,HDGF,CTDSP2,KDELR3,KLHDC3,CXXC1,WIPI1,FKBP14 |
| Apoptotic execution phase | GAS2,HIST1H1E,BMX,BCAP31,CASP6L2,HIST1H1C,DFFA,SATB1,HIST1H1A,CTNNB1 |
Protein Function
ADD1 has several biochemical functions, for example, actin binding,actin filament binding,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADD1 itself. We selected most functions ADD1 had, and list some proteins which have the same functions with ADD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | GM5506,MYOM1,GRHPR,ZHX3,PDZD7,RAB11FIP2,CHUK,ACHE,CRYAB,AMICA1 |
| protein heterodimerization activity | IL12A,HIST1H4B,PVALB,RBP4,H2BFWT,TLR6,SMAD2,PPP2R1A,HIST1H4H,ADD2 |
| transcription factor binding | GTF2B,GATA6,GTF2F1,IFI16,TFDP2,HDAC9,KAT6B,EP300,MAPK1,C1QBP |
| actin binding | EPS8L1,CORO7,MYH7B,MYH1E,AFAP1,SPIRE2,SPTBN1,YWHAH,SPIRE1,FBXO25 |
| protein binding | SEC22B,NAT9,PWWP2B,L3MBTL2,PPM1K,LPXN,KLC1,UBE2H,ADRA2A,ATF6B |
| poly(A) RNA binding | RPS19,C1orf53,GTPBP4,NME1,DDX23,LLPH,KPNB1,RBMS2,CCDC124,RPL27A |
| actin filament binding | MAP1S,FSCN2,SSFA2,MARCKS,SCIN,FSCN2A,PLDN,MACF1,SYNE2,ACTN2 |
| structural molecule activity | KRT222,KRT18,Sprr2i,SPRR2D,MAP7D2A,VCLA,LOR,CLDNC,CLDN20,LELP1 |
| calmodulin binding | CALD1B,PCDP1,MAP6D1,PDE1B,MYO1A,ITPKA,KCNQ1,TRPV5,KCNN1,RIT2 |
Interacting Protein
ADD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADD1.
RFX1;saicar;PKM;TK1;CSNK2B;ppdK;icmF1;mfd;q8czf9_yerpe;chbG;MAP1LC3B;GEMIN7;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;DST;ssdna_dtdg;TPM3
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