ADAT1
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Official Full Name
adenosine deaminase, tRNA-specific 1 -
Overview
This gene is a member of the ADAR (adenosine deaminase acting on RNA) family. Using site-specific adenosine modification, proteins encoded by these genes participate in the pre-mRNA editing of nuclear transcripts. The protein encoded by this gene, tRNA-specific adenosine deaminase 1, is responsible for the deamination of adenosine 37 to inosine in eukaryotic tRNA. Alternatively spliced transcript variants have been described. -
Synonyms
ADAT1;adenosine deaminase, tRNA-specific 1;tRNA-specific adenosine deaminase 1;adenosine deaminase acting on tRNA;tRNA-specific adenosine-37 deaminase;HADAT1
Recombinant Proteins
- Mouse
- Chicken
- Rhesus macaque
- Cynomolgus
- Human
- Zebrafish
- Mammalian Cell
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- T7
- Non
- GST
- His&GST
- His&Fc&Avi
Involved Pathway
ADAT1 involved in several pathways and played different roles in them. We selected most pathways ADAT1 participated on our site, such as Gene Expression,tRNA modification in the nucleus and cytosol,tRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| tRNA processing | WDR4,TSEN34,LCMT2,LAGE3,ADAT3,QTRT1,CDKAL1,FAM98B,TRMT11,TRMT61A |
| Gene Expression | TAF1D,FAUB,TH1L,OSGEP,SLBP,ZNF697,GTF3AA,TRMT6,ZNF606,ZNF434 |
| tRNA modification in the nucleus and cytosol | QTRT1,TYW5,LBH,TRMT6,TRMT44,TYW3,TP53RK,ADAT2,TRMT61A,LAGE3 |
Protein Function
ADAT1 has several biochemical functions, for example, RNA binding,metal ion binding,tRNA-specific adenosine deaminase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAT1 itself. We selected most functions ADAT1 had, and list some proteins which have the same functions with ADAT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ACMSD,STEAP4,C6AST3,ZNF428,RARGA,ZNF287,EBF1,RHEB,Gh,ACAT1 |
| RNA binding | AKAP1,PUSL1,PUS10,RPS4Y1,SKIV2L,IGHMBP2,DDX25,C14orf166,KIAA0430,OAS1B |
Interacting Protein
ADAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAT1.
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References
- Luo, M; Schramn, VL; et al. Transition state structure of E. coli tRNA-specific adenosine deaminase. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 130:2649-2655(2008).
- Kim, J; Malashkevich, V; et al. Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase. BIOCHEMISTRY 45:6407-6416(2006).
