ADARB1
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Official Full Name
adenosine deaminase, RNA-specific, B1 -
Overview
This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. -
Synonyms
ADARB1;adenosine deaminase, RNA-specific, B1;adenosine deaminase, RNA specific, B1 (homolog of rat RED1);double-stranded RNA-specific editase 1;ADAR2;ADAR2a;ADAR2a L1;ADAR2a L2;ADAR2a L3;ADAR2b;ADAR2c;ADAR2d;ADAR2g;DRABA2;DRADA2;hRED1;RED1;RED1 homolog (rat);ADARB 1;1700057H01Rik;Adenosine deaminase, RNA specific, 2;Adenosine deaminase, RNA specific, B1 (RED1 homolog rat);Adenosine deaminase, RNA specific, B1;AW124433;AW558573;BB220382;D10Bwg0447e;Double stranded RNA specific editase 1;dsRNA adenosine deaminase;EC 3.5.-.-;Human dsRNA adenosine deaminase DRADA2;Human dsRNA adenosine deaminase DRADA2b, EC 3.5;OTTHUMP00000115341;OTTHUMP00000115342;RED 1;RNA editase;RNA editase 1;RNA editing deaminase 1;RNA editing enzyme 1;RNA editing enzyme 1, rat, homolog of;RNA specific adenosine deaminase B1;RED1 homolog;OTTHUMP00000115339;OTTHUMP00000115340;OTTHUMP00000174981;OTTHUMP00000214128;RNA-editing enzyme 1;RNA-editing deaminase 1;dsRNA ad
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- Wheat Germ
- Mammalian Cell
- HEK293
- E.coli
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
ADARB1 involved in several pathways and played different roles in them. We selected most pathways ADARB1 participated on our site, such as C6 deamination of adenosine,Formation of editosomes by ADAR proteins,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADARB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Formation of editosomes by ADAR proteins | ADAR,ADARB1A |
| mRNA Editing | APOBEC1,A1CF,ADARB1A |
| C6 deamination of adenosine | ADARB1A,ADAR |
| mRNA Editing: A to I Conversion | ADARB1A |
| Gene Expression | PTBP1A,CTGF,PHF19,SMG9,APOBEC1,ZNF486,THG1L,SET,CD2BP2,YAP1 |
Protein Function
ADARB1 has several biochemical functions, for example, RNA binding,adenosine deaminase activity,double-stranded RNA adenosine deaminase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADARB1 itself. We selected most functions ADARB1 had, and list some proteins which have the same functions with ADARB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | FAU,RBM39A,UBR5,SMN1,RBMS3,SYNCRIP,ZMAT4,RNMTL1A,SF3A1,KHDC1A |
| double-stranded RNA binding | TUBA1B,ZFP346,OAS1B,ELAVL1,DHX15,AGO1,HSPD1,MBNL1,VIM,RNASEN |
| double-stranded RNA adenosine deaminase activity | ZBP1,PKZ,ADAR |
| adenosine deaminase activity | CECR1A,ADARB2,ADAD2,ADA,ADAD1,ADARB1A,ADAL,CECR1 |
| metal ion binding | AGFG1B,ZSCAN16,IMPDH2,THAP5,ZNF791,ZNF621,CLCA2,MTHFS,DGKAA,PRDM1A |
| mRNA binding | DPPA5A,RPS5,DOM3Z,CPSF6,KHSRP,NCBP2,RPL35,CSTF2T,EDC3,HNRNPAB |
| protein binding | FAAH,GBAS,TAX1BP3,RPL12,MORN2,CLC,STT3A,UGP2,C14orf159,LARP7 |
| poly(A) RNA binding | DYNC1H1,RRP7A,GANAB,XRCC5,EWSR1,HSP90AA1,NMD3,LUC7L2,LSM8,PUS7 |
Interacting Protein
ADARB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADARB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADARB1.
PIN1;WWP2;HNRNPA1;Rpl35;Ufl1
Resources
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References
- Allegra, D; Bilan, V; et al. Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia. LEUKEMIA 28:98-107(2014).
- Mertens, D; Allegra, D; et al. ADARB1 Is Involved In a Reduced Maturation Of The miR15a/Mir-16-1 Family In Chronic Lymphocytic Leukemia. BLOOD 122:-(2013).
